Table 1 Selective non-invasive indices of arterial stiffness/compliance (from Schillaci and Parati5, by permission)

From: Information on arterial properties from home blood pressure monitoring: work still in progress

Index

Method

Availability

Advantages

Disadvantages

Elastic modulus

Ultrasound (or MRI)+BP

+

Requires no assumptions from circulation models

Requires echotracking systems or MRI

Arterial distensibility

   

Problems with local BP estimate

Arterial compliance

   

Requires considerable expertise

PWV (carotid–femoral)

Pulse signal (any type)

++

Gold standard for arterial stiffness

Lack of consistency between different techniques

    

Limited accuracy in measuring distance

PWV (brachial–ankle)

Pulse signal (any type)

+++

Easier to measure than carotid–femoral PWV

As above

    

Based on anomalous transit tract

Aortic augmentation index

BP waveform

+++

Reflects left ventricular load and coronary blood flow

Indirect index for arterial stiffness

    

Needs pressure wave calibration

    

Controversial accuracy of arterial transfer function

Oscillatory compliance

BP waveform

+++

Fast acquisition

Needs theoretical assumptions (Windkessel model)

   

No specific expertise

 

Brachial PP

BP

++++

Obtainable with any BP measurement

Influenced by PP amplification, heart rate, vasodilatation, SV

PP/SV

Echocardiography+BP

++

Integrates ventricular and vascular function

Problems with SV calculation and peripheral PP

    

Based on a two-element hydraulic system

Pulse wave arrival time (QKd)

EKG+ambulatory BP

+++

No dedicated equipment

Influenced by height, pre-ejection time

Ambulatory arterial stiffness index

Ambulatory BP

+++

No dedicated equipment

Influenced by day–night BP reduction, systolic/diastolic BP correlation

  1. Abbreviations: BP, blood pressure; EKG, electrocardiogram; MRI, magnetic resonance imaging; PP, pulse pressure; PWV, pulse wave velocity; QKd, interval between onset of QRS and detection of last Korotkoff sound during brachial BP measurement; SV, stroke volume.