Table 3 Comparison of characteristics between OPN-156del/del and -156G genotype groups with or without diabetes
Non Diabetes (n=23) | Diabetes (n=95) | |||||
|---|---|---|---|---|---|---|
Variable | del/del (n=140) | G/del+G/G (n=83) | P-value | del/del (n=50) | G/del+G/G (n=45) | P-value |
Gender (male/female) | 77/63 | 47/36 | 0.889 | 37/13 | 28/17 | 0.271 |
Age (years) | 62.8±9.2 | 61.6±9.8 | 0.370 | 64.1±9.7 | 64.8±8.2 | 0.690 |
BMI (kg m−2) | 24.0±3.6 | 23.9±3.5 | 0.823 | 24.0±3.7 | 24.4±3.3 | 0.568 |
Systolic blood pressure (mm Hg) | 162.3±±25.6 | 161.9±30.7 | 0.921 | 147.9±27.0 | 144.9±25.9 | 0.668 |
Diastolic blood pressure (mm Hg) | 95.8±15.7 | 95.7±17.8 | 0.976 | 85.5±16.4 | 85.3±14.4 | 0.958 |
Antihypertensive drug treatment | 67 (48.2%) | 42 (50.6%) | 0.782 | 24 (48.0%) | 24 (53.3%) | 0.683 |
Calcium channel blockers | 48 (34.5%) | 29 (34.9%) | 1.000 | 14 (28.0%) | 14 (31.1%) | 0.823 |
ACE inhibitors and/or ARBs | 36 (25.9%) | 24 (28.9%) | 0.642 | 16 (32.0%) | 14 (31.1%) | 1.000 |
ACE inhibitors | 21 (15.1%) | 9 (10.8%) | 0.422 | 9 (18.0%) | 8 (17.8%) | 1.000 |
ARBs | 18 (12.9%) | 15 (18.1%) | 0.332 | 9 (18.0%) | 8 (17.8%) | 1.000 |
β-Blockers | 13 (9.4%) | 11 (13.3%) | 0.379 | 4 (8.0%) | 4 (8.9%) | 1.000 |
α-Blockers | 4 (2.9%) | 1 (1.2%) | 0.653 | 6 (3.2%) | 2 (1.6%) | 1.000 |
Diuretics | 9 (6.5%) | 5 (6.1%) | 1.000 | 8 (16.0%) | 6 (13.3%) | 0.778 |
Diabetes | ||||||
HbA1c (%) | 5.0±0.4 | 5.0±0.4 | 0.432 | 7.2±1.4 | 7.3±1.3 | 0.651 |
Fasting blood glucose (mg dl−1) | 97.4±22.0 | 98.2±13.4 | 0.768 | 152.5±69.0 | 144.6±41.9 | 0.510 |
Hyperlipidemia | 75 (53.6%) | 42 (50.6%) | 0.680 | 27 (54.0%) | 23 (51.1%) | 0.838 |
Total cholesterol (mg dl−1) | 208.6±37.0 | 209.3±36.8 | 0.887 | 201.1±37.5 | 193.1±33.4 | 0.278 |
Triglyceride (mg dl−1) | 144.9±73.1 | 151.3±103.7 | 0.604 | 141.8±117.6 | 142.0±71.3 | 0.991 |
HDL (mg dl−1) | 54.9±17.4 | 53.9±14.2 | 0.665 | 51.9±15.0 | 50.7±12.7 | 0.678 |
Diabetes-related treatment | — | — | — | 37 (75.5%) | 34 (75.6%) | 1.000 |
Lipid-lowering treatment | 22 (15.8%) | 18 (21.7%) | 0.284 | 15 (30.0%) | 14 (31.1%) | 1.000 |
Coronary heart disease | 11 (7.9%) | 9 (10.8%) | 0.474 | 7 (14.0%) | 9 (20.0%) | 0.584 |
