Table 4 Summary of renal mRNA expression
From: Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells
Gene | WT/con | Tg/con | WT/aldo | Tg/aldo | Expected additive effect | Significance (P< 0.05) |
|---|---|---|---|---|---|---|
Extracellular matrix | ||||||
Fn-1 | 1.0±0.4 | 3.1±0.7 | 10.7±4.2 | 3.9±1.2 | 12.8 | (1) WT/aldo vs. WT/con (2) Tg/con vs. WT/con |
Col1a1 | 1.0±0.2 | 1.9±0.3 | 7.7±2.8 | 6.7±2.4 | 8.6 | (1) WT/aldo vs. WT/con (2) Tg/aldo vs. Tg/con (3) Tg/con vs. WT/con |
Col3a1 | 1.0±0.3 | 2.0±0.4 | 3.1±0.8 | 4.2±1.1 | 4.1 | (1) WT/aldo vs. WT/con (2) Tg/aldo vs. Tg/con |
Col4a1 | 1.0±0.3 | 1.6±0.3 | 3.3±0.9 | 3.1±0.4 | 3.9 | (1) WT/aldo vs. WT/con (2) Tg/aldo vs. Tg/con |
PAI-1 | 1.0±0.3 | 1.2±0.3 | 1.8±0.4 | 1.1±0.2 | 2.0 | |
Proinflammation | ||||||
CCL-5 | 1.0±0.2 | 10.6±2.8 | 2.8±0.5 | 4.2±1.3 | 12.2 | Tg/con vs. WT/con |
MCP-1 | 1.0±0.2 | 2.3±0.6 | 2.4±0.6 | 1.8±0.1 | 3.7 | |
SPP-1 | 1.0±0.1 | 1.1±0.3 | 1.7±0.4 | 1.5±0.1 | 1.8 | |
TNF-α | 1.0±0.4 | 3.0±0.8 | 3.8±1.6 | 1.9±0.6 | 5.8 | |
