Table 5 Summary of cardiac mRNA expression

From: Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells

Gene

WT/con

Tg/con

WT/aldo

Tg/aldo

Expected additive effect

Significance (P< 0.05)

Extracellular matrix

Fn-1

1.0±0.5

0.2±0.0

0.9±0.4

1.4±0.6

0.1

 

Col1a1

1.0±0.3

0.4±0.1

1.7±0.6

1.6±0.7

1.1

 

Col3a1

1.0±0.4

0.4±0.2

0.9±0.3

0.9±0.4

0.3

 

Col4a1

1.0±0.4

0.3±0.0

1.1±0.2

1.1±0.3

0.4

 

PAI-1

1.0±0.2

1.1±0.2

2.0±0.4

0.7±0.2

2.1

WT/aldo vs. WT/con

Proinflammation

 CCL-5

1.0±0.4

0.4±0.1

2.8±1.1

2.0±1.3

2.2

 

 MCP-1

1.0±0.2

1.8±0.6

3.2±0.9

2.7±1.1

4.0

WT/aldo vs. WT/con

 SPP-1

1.0±0.5

0.8±0.2

2.8±1.4

1.9±0.8

2.6

 

 TNF-α

1.0±0.1

1.2±0.2

1.8±0.2

2.0±0.6

2.0

WT/aldo vs. WT/con

  1. Abbreviations: aldo, aldosterone; CCL-5, chemokine ligand-5; Col1a1, collagen I; Col3a1, collagen III; Col4a1, collagen IV; con, control; Fn-1, fibronectin-1; MCP-1, monocyte chemoattractant protein-1; PAI-1, plasminogen activator inhibitor-1; SPP-1, secreted phosphoprotein-1/osteopontin; Tg, transgenic; TNF-α, tumor necrosis factor-α; WT, wild type.
  2. N=4–6 animals per group.
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