Figure 2
Changes in heart rate after and glomerular microcirculation acute injection of amlodipine or azelnidipine. Systolic blood pressure (a) and heart rate (b) were recorded for 30 min after amlodipine (Amlo; 0.5 mg kg−1) or azelnidipine (Azel; 0.1 mg kg−1) injection (i.v. in Dahl salt-sensitive rats under anesthesia. n=5 for each group. *P<0.05 vs. Amlo. (c) Morphological changes in glomeruli before and 20 min after injection of amlodipine or azelnidipine in Dahl salt-sensitive rats under anesthesia. Af, afferent arteriole; Ef, efferent arteriole. (d) Changes in afferent and efferent arteriole diameter after injection of amlodipine (Amlo) or azelnidipine (Azel). n=5 for each group. *P<0.05 vs. before treatment; †P<0.05 vs. Amlo.
