Figure 2 | Hypertension Research

Figure 2

From: Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension

Figure 2

Cardiomyocyte size and expression of fetal-type cardiac genes in the left ventricle (LV) of Dahl salt-sensitive (DS) rats in the five experimental groups at 11 weeks of age. (a) Hematoxylin-eosin staining of transverse sections of the LV myocardium. Scale bars, 30.1 μm. (b) Cross-sectional area of cardiac myocytes determined from sections similar to those in (a). (c, d) Quantitative reverse-transcription (RT)-PCR analysis of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNAs, respectively. The amount of each mRNA was normalized by that of 18S rRNA and then expressed relative to the mean value for the CONT group. Data in (b) through (d) are means±s.e.m. (n=6 rats per group). *P<0.05 vs. CONT; †P<0.05 vs. left ventricular hypertrophy (LVH); ‡P<0.05 vs. losartan (LOS); §P<0.05 vs. hydrochlorothiazide (HCTZ).

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