Table 3 Risks associated with the systolic home blood pressure at baseline and during follow-up in 3518 participants

From: Cardiovascular outcomes in the first trial of antihypertensive therapy guided by self-measured home blood pressure

  

Baseline

Follow-up

End point (number)

Model

Hazard ratio (95% CI)

P-value

Hazard ratio (95% CI)

P-value

Primary end point (51)

Adjusted

1.57 (1.19–2.08)

0.0015

1.60 (1.26–2.04)

0.0002

 

Fully adjusted

1.41 (1.06–1.89)

0.019

1.47 (1.15–1.87)

0.0020

Fatal plus non-fatal end points

 All cardiovascular (106)

Adjusted

1.34 (1.11–1.62)

0.0026

1.47 (1.23–1.75)

<0.0001

 

Fully adjusted

1.21 (0.99–1.47)

0.065

1.44 (1.21–1.72)

<0.0001

 Stroke (36)

Adjusted

1.40 (1.01–1.95)

0.046

1.59 (1.20–2.11)

0.0011

 

Fully adjusted

1.24 (0.88–1.76)

0.22

1.53 (1.14–2.05)

0.0046

 Ischemic heart disease (53)

Adjusted

1.35 (1.03–1.76)

0.029

1.37 (1.08–1.75)

0.010

 

Fully adjusted

1.25 (0.94–1.65)

0.12

1.32 (1.04–1.69)

0.026

 Myocardial infarction (12)

Adjusted

1.75 (0.99–3.10)

0.055

1.68 (1.05–2.69)

0.030

 

Fully adjusted

1.55 (0.84–2.83)

0.16

1.57 (0.98–2.50)

0.058

Mortality

 Total (58)

Adjusted

1.04 (0.79–1.35)

0.80

1.24 (0.99–1.57)

0.067

 

Fully adjusted

0.98 (0.75–1.29)

0.90

1.25 (0.97–1.60)

0.080

 Cardiovascular (8)

Adjusted

2.33 (1.11–4.91)

0.026

1.71 (0.89–3.28)

0.11

 

Fully adjusted

2.22 (1.03–4.80)

0.041

1.46 (0.77–2.74)

0.24

 Non-cardiovascular (50)

Adjusted

0.91 (0.68–1.22)

0.54

1.17 (0.91–1.52)

0.22

 

Fully adjusted

0.87 (0.64–1.17)

0.36

1.22 (0.94–1.59)

0.14

  1. Hazard ratios express the risk associated with 1-s.d. increase in systolic home blood pressure. The s.d.s were 12.5 and 13.2 mm Hg for the home blood pressure at baseline and follow-up, respectively. The co-variables in adjusted model were randomization group and baseline characteristics: sex, age, body mass index, current smoking and drinking, history of cardiovascular disease, diabetes mellitus and hypercholesterolemia. In fully adjusted models, the baseline home blood pressure was additionally adjusted for the home blood pressure during follow-up and vice versa. Fully adjusted models include the same co-variables. The correlation coefficients between the baseline and follow-up home blood pressures were 0.24–0.25.
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