Figure 1a and b

Changes in systolic arterial pressure (a) and heart rate (b) for Wistar-Kyoto rats treated with vehicle (WKY), spontaneously hypertensive rats treated with vehicle (SHR), spontaneously hypertensive rats treated with nitroglycerin (SHR-N) and spontaneously hypertensive rats treated with esmolol (SHR-E). Data were obtained at 0, 12, 24, 36 and 48 h of treatment. Values are given as mean±s.d. Statistically significant differences are shown: *P<0.05 vs. WKY; †P<0.01 vs. WKY; ‡P<0.001 vs. WKY; ∥P<0.01 vs. SHR; #P<0.001 vs. SHR; ‡‡P<0.001 vs. SHR-E, corrected for multiple comparisons-Bonferroni.