Table 4 Histological variables in two subregions of the LV of WKY and SHR groups

From: Early regression of left ventricular hypertrophy after treatment with esmolol in an experimental rat model of primary hypertension

 

WKY (n=9)

SHR (n=8)

SHR-E (n=8)

SHR-N (n=8)

P-value ANOVA

CSA (μm2) subepicardium

140±22

321±55‡

165±23*,#

315±12‡,‡‡

<0.001

CSA (μm2) subendocardium

139±21

283±78‡

142±11#

276±21‡,‡‡

<0.001

CVF (%) subepicardium

6.04±2.69

10.01±2.68*

11.26±3.08†

9.03±2.54*

0.020

CVF (%) subendocardium

11.80±6.69

24.92±4.68†

24.99±6.37†

22.80±3.96†

0.009

  1. Abbreviations: ANOVA, analysis of variance; CSA, cross-sectional area of cardiomyocytes; CVF, collagen volume fraction; SHR, spontaneously hypertensive rats treated with vehicle; SHR-E, spontaneously hypertensive rats treated with esmolol; SHR-N, spontaneously hypertensive rats treated with nitroglycerin; WKY, Wistar-Kyoto rats treated with vehicle
  2. Statistically significant differences between WKY, SHR, SHR-N and SHR-E are shown (*P<0.05 vs. WKY; †P<0.01 vs. WKY; ‡P<0.001 vs. WKY; #P<0.001 vs. SHR; ‡‡P<0.001 vs. SHR-E). Values are given as mean±s.d. ANOVA, CSA, CVF.
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