Table 1 Hemodynamics and cardiac parameters

From: Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation

 

WT Saline

SA/SA Saline

WT ANG II

SA/SA ANG II

SBP

 Before

—

—

122.5±2.6 (6)

124.5±0.7 (4)

 After

—

—

161.8±3.0 (6)a

166.9±3.4 (4)a

DBP

 Before

—

—

85.8±1.0 (6)

89.2±1.7 (4)

 After

—

—

112.0±4.3 (6)a

122.2±3.5 (4)a

MAP

 Before

—

—

105.0±2.0 (6)

104.8±1.8 (4)

 After

—

—

135.4±3.0 (6)a

142.9±3.3 (4)a

HR

 Before

—

—

592.5±20.6 (6)

594.3±10.5 (4)

 After

—

—

552.7±16.6 (6)

568.7±14.2 (4)

EF

 Before

63.0±2.0 (3)

61.0±2.2 (3)

72.6±10.0 (5)

63.7±7.1 (5)

 After

62.6±1.8 (3)

58.7±1.8 (3)

71.5±0.8 (5)

51.7±6.9 (5)b

FS

 Before

33.0±1.7 (3)

32.2±1.5 (3)

35.5±4.4 (5)

34.3±4.9 (5)

 After

33.4±0.7 (3)

31.3±0.8 (3)

40.0±0.6 (5)

26.4±4.3 (5)b

HW/BW (mg/g)

5.50±0.23 (4)

5.22±0.30 (3)

7.31±0.23 (6)c

6.24±0.19 (5)d,e

VEGF (pg/μg)

47.47±3.03 (3)

44.20±4.47 (3)

64.13±6.24 (7)

46.18±4.44 (4)

MCP-1 (pg/μg)

1.50±0.79 (3)

1.10±0.21 (3)

35.14±2.58 (7)c

22.28±1.56 (4)d,f

TGF-β1 (pg/μg)

8.30±0.91 (3)

6.13±0.43 (3)

56.40±4.38 (7)c

38.00±2.86 (4)d,f

IL-6 (pg/μg)

3.93±0.65 (3)

3.00±0.06 (3)

13.59±1.41 (7)c

9.05±0.56 (4)b,e

  1. Abbreviations: ANG II, angiotensin II; BW, body weight; DBP, diastolic blood pressure; EF, ejection fraction; FS, fractional shortening; HR, heart rate; HW, heart weight; MAP, mean arterial pressure; SBP, systolic blood pressure; SA/SA, mice with S727A mutation; WT, wild-type.
  2. Numbers in parentheses represent the number of mice in each group.
  3. Data were analyzed by Student’s t test (Before vs After) or one-way ANOVA with Newman-Keuls multiple comparison test.
  4. aP<0.001 vs respective Before value.
  5. bP<0.05 vs WT ANG II.
  6. cP<0.001 vs WT Saline.
  7. dP<0.01 vs WT ANG II.
  8. eP<0.05 vs SA/SA Saline.
  9. fP<0.001 vs SA/SA Saline.
Back to article page