Table 3 Effects of antihypertensive treatment on clinical characteristics and standard echocardiography in the hypertensive patients
HT with LV systolic dyssynchrony (Group 1, n=29) | HT without LV systolic dyssynchrony (Group 2, n=31) | |||||||
|---|---|---|---|---|---|---|---|---|
Baseline | After 6 months | Δ change (95% CI) | P-values (paired t-test) | Baseline | After 6 months | Δ change (95% CI) | P-values (paired t-test) | |
SBP (mm Hg) at office | 162±17 | 128±11 | −34 (−39 to −28) | <0.001 | 157±17 | 130±10 | −27 (−34 to −19) | <0.001 |
DBP(mm Hg) at office | 98±14 | 80±6 | −18 (−23 to −14) | <0.001 | 96±11 | 83±9 | −13 (−18 to −9) | <0.001 |
QRS duration (ms) | 85±15 | 82±13 | −3 (−8 to 3) | 0.250 | 86±13 | 84±13 | −2 (−7 to 3) | 0.323 |
Heart rate (beats per minute) | 68±8 | 68±10 | 0.0 (−5 to 4) | 0.936 | 69±10 | 69±11 | 0.0 (−4 to 3) | 0.798 |
LV size and function | ||||||||
Ejection fraction (%) | 64.7±5.6 | 66.1±7.2 | 1.4 (−1.3 to 4.1) | 0.294 | 64.4±7.5 | 63.6±7.5 | −0.7 (−4.2 to 2.7) | 0.672 |
End-diastolic volume (ml) | 68.7±18.9 | 66.0±17.1 | −2.7 (−9.1 to 3.7) | 0.397 | 64.3±20.0 | 63.4±17.9 | −0.9 (−7.3 to 5.6) | 0.786 |
End-systolic volume (ml) | 24.5±8.4 | 22.6±7.9 | −1.9 (−5.4 to 1.5) | 0.262 | 23.5±10.5 | 22.8±7.7 | −0.7 (−4.5 to 3.0) | 0.698 |
LV mass index (g m−2) | 102.5±33.1 | 90.4±24.2 | −12.1 (−21.8 to −2.3) | 0.017 | 106.0±30.3 | 94.6±25.7 | −11.4 (−23.0 to 0.1) | 0.052 |
Mitral E wave (cm s−1) | 74.4±18.1 | 76.8±19.3 | 0.12 (0.02 to 0.22) | 0.339 | 66.5±14.6 | 68.2±16.6 | 0.07 (−0.02 to 0.15) | 0.551 |
Mitral E/A ratio | 0.94±0.26 | 1.05±0.31 | −4.1 (−24.0 to 15.7) | 0.022 | 0.93±0.36 | 1.00±0.37 | 0.0 (−22 to 22) | 0.135 |
Deceleration time of mitral E (ms) | 181±45 | 177±37 | −0.6 (−1.5 to 0.3) | 0.672 | 199±60 | 198±51 | −1.1 (−2.0 to −0.3) | 0.979 |
Isovolumic relaxation time (ms) | 84±22 | 82±21 | 0.7 (0.2 to 1.3) | 0.315 | 86±25 | 91±21 | 0.5 (−0.1 to 1.0) | 0.263 |
Mitral E/E′(average of septal and lateral annulus) | 9.9±2.2 | 9.3±2.3 | 1.0 (0.5 to 1.5) | 0.165 | 9.6±2.0 | 8.5±2.6 | 0.8 (0.4 to 1.2) | 0.012 |
Mean annulus S′ (cm s−1) | 7.6±1.0 | 8.3±1.4 | 0.1 (−0.4 to 0.7) | 0.012 | 7.9±1.3 | 8.4±1.3 | 0.1 (−0.4 to 0.5) | 0.084 |
Mean annulus E′ (cm s−1) | 7.5±2.3 | 8.6±2.6 | 0.09 (0.01 to 0.17) | <0.001 | 7.4±2.5 | 8.2±2.5 | 0.08 (0.02 to 0.13) | <0.001 |
Mean annulus A′ (cm s−1) | 10.2±1.6 | 10.3±1.4 | 1.4 (−1.3 to 4.1) | 0.670 | 9.5±1.4 | 9.6±1.3 | −0.7 (−4.2 to 2.7) | 0.833 |
Mean annulus E′/A′ ratio | 0.76±0.26 | 0.85±0.28 | −2.7 (−9.1 to 3.7) | 0.021 | 0.80±0.31 | 0.87±0.32 | −0.9 (−7.3 to 5.6) | 0.005 |
