Table 4 Effects of antihypertensive treatment on dyssynchrony in the hypertensive patients

	HT with LV systolic dyssynchrony (Group 1, n=29)				HT without LV systolic dyssynchrony (Group 2, n=31)
	Baseline	After 6 months	Δ change (95% CI)	P-values (paired t-test)	Baseline	After 6 months	Δ change (95% CI)	P-values (paired t-test)
LV systolic dyssynchrony
Ts-SD12 (ms)	48.6±11.1^*	35.6±16.5†	−13.1 (−19.8 to −6.4)††	<0.001	23.1±8.3	25.0±15.7	1.9 (−5.3 to 9.1)	0.592
Ts-Max (ms)	133.4±38.2^*	99.4±43.6†	−34.0 (−55.2 to −12.9)††	0.003	99.4±27.3	72.7±45.1	4.7 (−16.8 to 26.1)	0.659
Ts-LS (ms)	89.4±38.4^*	57.7±89.4†	−31.6 (−50.9 to −12.4)††	0.002	21.8±23.9	32.5±29.3	10.7 (−3.5 to 24.9)	0.134
LV diastolic dyssynchrony
Te-SD12 (ms)	21.0±8.1	19.8±6.7	−1.2 (−4.1 to 1.7)	0.414	24.0±12.9	23.7±12.2	−0.3 (−5.1 to 4.5)	0.893
Te-Max (ms)	69.5±26.1	61.2±19.5	−8.3 (−18.3 to 1.8)	0.102	74.7±36.8	74.4±37.7	−0.3 (−14.2 to 13.5)	0.960
Contractile diastolic dyssynchrony
oExcT (ms)	559.7±329.4	431.0±208.7	−128.7 (−275.4 to 18.0)	0.083	526.8±305.4	400.4±162.5	−126.4 (−243.8 to -9.0)	0.036

Abbreviations: CI, confidence interval; HT, hypertension; LV, left ventricular; n, number; oExcT, sum of the time of strain tracing exceeding aortic valve closure on the overall 12 LV segments; Te-Max, maximal difference between peak early diastolic velocities of any 2 of the 12 LV segments; Te-SD12, s.d. of 12 LV segments time-to-peak early diastolic velocities; Ts-LS, time delay between time-to-peak systolic velocities at the LV basal lateral and septal segments; Ts-Max, maximal difference between peak systolic velocities of any 2 of the 12 segments; Ts-SD12, s.d. of 12 LV segments time-to-peak systolic velocities; Δ, value of follow-up minus value of baseline.
Values are arithmetic mean±s.d.
^*P<0.05 vs. baseline in group 2. †P<0.05 vs. after 6 months in group 2. ††P<0.05 vs. Δ change in group 2.

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