Table 3 SNPs associated with blood pressure responses to cold pressor test

From: Association between genetic variants of the ADD1 and GNB3 genes and blood pressure response to the cold pressor test in a Chinese Han population: the GenSalt Study

   

P-values

 

Gene

SNP

General model

Additive model

Dominant model

Recessive model

Systolic blood pressure

Reactivity AUC

ADD1

rs17833172

<0.0001*

0.68

0.50

<0.0001*

  

rs3775067

0.03

0.61

0.49

0.03

 

GNB3

rs4963516

0.64

0.72

0.95

0.40

Recovery AUC

ADD1

rs17833172

0.002*

0.66

0.90

0.0003*

  

rs3775067

0.01

0.15

0.88

0.004*

 

GNB3

rs4963516

0.26

0.47

0.19

0.64

Overall AUC

ADD1

rs17833172

0.0002*

0.77

0.96

<0.0001*

  

rs3775067

0.01

0.21

0.94

0.005

 

GNB3

rs4963516

0.31

0.63

0.28

0.55

Diastolic blood pressure

Reactivity AUC

ADD1

rs17833172

0.13

0.88

0.98

0.04

  

rs3775067

0.02

0.23

0.93

0.008

 

GNB3

rs4963516

0.40

0.18

0.27

0.29

Recovery AUC

ADD1

rs17833172

0.38

0.60

0.73

0.17

  

rs3775067

0.05

0.08

0.49

0.02

 

GNB3

rs4963516

0.006

0.002*

0.002*

0.09

Overall AUC

ADD1

rs17833172

0.36

0.62

0.75

0.16

  

rs3775067

0.04

0.09

0.57

0.01

 

GNB3

rs4963516

0.01

0.003*

0.005

0.10

  1. Abbreviations: ADD1, α-adducin; AUC, area under the curve; GNB3, guanine nucleotide binding protein (G protein) β-polypeptide 3; SNP, single-nucleotide polymorphism.
  2. *P-value <0.05 after Bonferroni correction. Original P-values <0.05 are indicated in bold.
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