Table 4 Association analysis of haplotypes with BP response to cold pressor test

From: Association between genetic variants of the ADD1 and GNB3 genes and blood pressure response to the cold pressor test in a Chinese Han population: the GenSalt Study

   

P-values

Genes

Haplotype sequence

Haplotype frequency

Reactivity AUC

Recovery AUC

Overall AUC

Systolic blood pressure

ADD1

TCTG

0.52

0.83

0.85

0.85

 

CTGC

0.33

0.86

0.004 c

0.008 c

 

CCGC

0.09

0.67

0.18

0.25

GNB3

GC

0.54

0.80

0.38

0.54

 

AC

0.26

0.23

0.06

0.07

 

AT

0.20

0.16

0.53

0.37

Diastolic blood pressure

ADD1

TCTG

0.52

0.19

0.46

0.37

 

CTGC

0.33

0.009 c

0.02 a /0.01 c

0.02 a /0.008 c

 

CCGC

0.09

0.04 b

0.001 a*/0.0005 b*

0.002 a*/0.0007 b*

GNB3

GC

0.54

0.74

0.22

0.27

 

AC

0.26

0.03 b

0.03 b

0.04 a /0.03 b

 

AT

0.20

0.10

0.03 c

0.04 c

  1. Abbreviations: ADD1, α-adducin; AUC, area under the curve; BP, blood pressure; GNB3, guanine nucleotide binding protein (G protein) β-polypeptide 3.
  2. For association not significant under any model, P-values for additive model are listed.
  3. For ADD1 gene, haplotype sequence is in the order of rs1263359–rs3775067–rs4961–rs4963. For GNB3 gene, haplotype sequence is in the order of rs2301339-rs5446. Original P-value <0.05 is indicated in bold.
  4. *P-values are significant after Bonferroni correction (P<0.004).
  5. aAdditive model.
  6. bDominant model.
  7. cRecessive.
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