Figure 4
From: Ethnic differences in genetic predisposition to hypertension
Phylogenetic relation of population-specific SNPs to ancestral haplotype on 12q24 involving the ALDH2 locus.3, 4, 5, 6 Two phylogenetically-independent haplotypes—H5 and H7—are assumed to affect BP in the east Asian and European populations, respectively.3, 4, 5 There are several clusters of SNPs with tight LD at 112.2–112.9 Mb (Build 37.3 drawn from Ensembl browser, http://www.ensembl.org/Homo_sapiens/), in which modest signatures of natural selection were detected5 as indicated by a horizontal arrow (a). Here, positions of east Asian-specific (rs671) and European-specific (rs11065987) SNPs are also depicted in the top panel (a). For clusters of SNPs located in this interval that shows limited recombination across the three populations—east Asian (Japanese), Caucasian (or whites) and blacks, we chose representative SNPs of each cluster and inferred their phylogeny (b) and haplotypes (c). rs11065987 and SH2B3 rs3184504 belong to the same cluster. Figures and tables are drawn from Supplementary materials of Kato et al.5
