Hypertension Research

Table 2 Univariate and stepwise multiple regression analysis for determinants of albuminuria, L-FABP and 8-OhdG in the aliskiren group

From: Additive renoprotective effects of aliskiren on angiotensin receptor blocker and calcium channel blocker treatments for type 2 diabetic patients with albuminuria

	Albuminuria				Urinary 8-OhdG				Urinary L-FABP
	Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
Factors	ρ	P	β	P	ρ	P	β	P	ρ	P	β	P
Albuminuria (%)					0.163	0.370	−1.172	0.153	0.133	0.465	0.239	0.138
Urinary 8-OHdG (%)	−0.066	0.708							0.535	0.0016	0.552	0.0005
Urinary L-FABP (%)	0.133	0.465	0.420	0.122	0.535	0.0016	0.547	0.0028
BMI (kg m⁻²)	0.170	0.349	−0.420	0.160	0.100	0.583			0.299	0.095
Systolic BP (mm Hg)	0.211	0.244			−0.095	0.604	−0.027	0.29	0.092	0.616
Diastolic BP (mm Hg)	0.128	0.484			0.118	0.518			0.007	0.966
eGFR (ml min⁻¹ per 1.73 m²)	−0.261	0.148			−0.069	0.705			−0.098	0.591
Fasting plasma glucose (%)	0.356	0.045			0.161	0.377			0.033	0.857
Hemoglobin A1c (%)	0.399	0.023	−0.239	0.010	0.062	0.734			−0.290	0.107
LDL-cholesterol (%)	0.358	0.044	0.361	0.120	−0.126	0.489			0.250	0.167
HDL-cholesterol (%)	0.038	0.833			0.380	0.0317	0.458	0.059	−0.121	0.509
Triglyceride (%)	0.231	0.203			−0.057	0.756			0.146	0.424	0.035	0.054
Plasma renin activity (%)	0.018	0.921			0.046	0.802			0.351	0.048
Aldosterone (%)	0.022	0.901			0.383	0.033	0.262	0.066	0.460	0.0081	0.392	0.0119
Hs-CRP (%)	0.140	0.443			−0.030	0.868			0.180	0.322
			R²=0.420				R²=0.577				R²=0.608

Abbreviations: BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; Hs-CRP, high-sensitivity C-reactive protein; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; LDL, low-density lipoprotein; L-FABP, liver-type fatty acid-binding protein.

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