Table 1 Renal disease QTL identified in genome-wide linkage analyses of genetic rat models

From: Mapping genetic determinants of kidney damage in rat models

Cross

Ref.

Sex

Treatment

Week

Phenotype

QTL on RNO

BUF × WKY BC

19, 24

m

Normal diet

20–60

Proteinuria

13

FHH × ACI BC

77

m

Normal diet

36

Proteinuria

1 (Rf-1), 1 (Rf-2)

    

36

Focal glomerulosclerosis

1 (Rf-1), 1 (Rf-2)

FHH × ACI F2

90

m

Normal diet, Nx

14

Albuminuria

1 (Rf-1), 1 (Rf-2), 1 (Bpfh1), 3, 14, 17

    

14

Proteinuria

1 (Rf-1), 1 (Rf-2), 1 (Bpfh1), 3, 14, 17

    

14

Focal glomerulosclerosis

1 (Rf-1), 1 (Rf-2), 3, 14

FHH.1BN × FHH F2

91

f

0.4% NaCl

20

Renal blood flow autoregulation

1

GK × BN F2

114

m

1% NaCl

12, 24, 36, 48

Proteinuria

5, 7

    

48

Glomerulosclerosis

5, 7

    

48

Tubular sclerosis

5, 7

    

12, 24, 36, 48

Diabetes phenotypes

1, 4, 5, 10

LH × LN F2

124, 126

m

0.3% NaCl

29–31

Creatinine levels

1, 2, 17

     

Kidney weight

1, 2, 3, 10, 17

MWF × Lew BC

141

m

0.2% NaCl

8, 14, 24

Albuminuria

1 (QTL1), 6 (QTL1), 12, 17

    

8, 14, 24

Proteinuria

1 (QTL1), 17

    

24

Superficial glomeruli

X

    

24

Surface glomeruli

1, 13

MWF × SHR BC

142

m

0.2% NaCl

8, 14, 24

Albuminuria

1 (QTL2), 4, 6 (QTL2), 7, 8, 9, 15, X

    

8, 14, 24

Proteinuria

1 (QTL2), 6, 8, 15

    

24

Renal interstitial fibrosis

6

    

24

Superficial glomeruli

2, 6, 7, 9

    

24

Surface glomeruli

6

SBH × SBN F2

152

m

0.2% NaCl, Nx

12, 20, 24, 28, 32

Proteinuria

2, 3, 17, 20

SBH × SBN BC

150

m

0.2% NaCl, Nx

16

Proteinuria

2, 6, 9, 20

  

f

0.2% NaCl, Nx

20

Proteinuria

11, 13, 20

SHR-A3 × SHR-B2 F2

168

m

0.2% NaCl

25

Immunoglobulin G subclasses associated with albuminuria

6

SHRSP × SHR F2

176

m, f

1% NaCl

10

Renal vascular/parenchymal lesions

1 (QTL1+2), 4, 10, 16

SS × SHR F2

53

m

0.2% NaCl

14

Albuminuria

2, 6 (QTL2), 8, 9, 10, 11, 19

SS × SHR BC

54

m

0.3% NaCl

8, 12, 16

Albuminuria

1, 2, 6 (QTL2), 8, 9, 10, 11, 13, 19

    

8, 12, 16

Proteinuria

1, 2, 6 (QTL1+2), 8, 9, 10, 11, 19

    

16

Kidney lesion grade

2, 6, 8, 11, 13, 19

SS × SHR F2

61

m

2% NaCl

8, 12, 16

Albuminuria

1, 6 (QTL2), 8, 9, 13

    

8, 12, 16

Proteinuria

1, 6 (QTL2), 8, 9

    

16

Kidney lesion grade

1, 2, 8, 9, 13

SS × SHR F2

48

m

4% NaCl

14

Albuminuria

6 (QTL1+2), 8, 9, 19

    

14

Proteinuria

3, 6 (QTL1), 19

    

14

Renal interstitial fibrosis

20

    

14

Tubulointerstitial inflammation grading

3

    

14

Microangiopathy

5

SS × BN F2

62

f

0.4/0.1/8% NaCl

12

Proteinuria

2, 11

    

12

Focal glomerulosclerosis

2

    

12

Glomerular injury

11

  1. Abbreviations: ACI, August × Copenhagen Irish; BC, backcross; BN, Brown Norway; BUF, Buffalo; f, females; FHH, Fawn-hooded hypertensive; GK, Goto-Kakizaki; Lew, Lewis; LH, Lyon hypertensive; LN, Lyon normotensive; m, males; MWF, Munich Wistar Frömter; QTL, quantitative trait loci; Ref., reference; RNO, rat chromosome; SBH, Sabra hypertension prone; SBN, Sabra hypertension resistant; SHR, spontaneously hypertensive rat; SHRSP, spontaneously hypertensive rat, stroke prone; SS, Dahl salt-sensitive; WKY, Wistar-Kyoto.
  2. Statistical thresholds for significance in linkage analysis were used as recommended by Lander and Kruglyak205 and maximal logarithm of odds (LOD) score values in BC or F2 populations are given in bold when indicative for significant linkage.
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