Table 2 Confirmed renal disease QTL of genetic rat models by consomic and/or congenic studies

FHH × ACI ^{77, 90, 91, 92, 93, 94, 95, 96, 98, 101, 103, 104}

 ACI.FHH-(D1Rat74-D1Rat90) or Rf-1A

8.0% NaCl/

Proteinuria

1, 3

 ACI.FHH-(D1Rat298-D1Rat90) or Rf-1A

L-NAME/

Albuminuria

1, 3

 ACI.FHH-D1Mit34/Rat156 or ACI.FHH-Rf1B

Nx

Glomerular damage

1, 3

 ACI.FHH-(D1Rat324-D1Rat156) or Rf-1B

Autoregulation of renal blood flow

1

 ACI.FHH-(D1Rat384-D1Rat156) or Rf-1B

Susceptibility to renal failure

1+3, 1+14

 ACI.FHH-(D3Wox2-D3Rat59) or Rf-3

 Rf-3_b (D3Got102-D3Got121)

 ACI.FHH-(D1Rat475-D1Rat90)/(D3Rat84-D3Rat59) or Rf-1A+3

 ACI.FHH-(D1Mit18-D1Rat90)/(D14Mit11-D14Rat33/D14Rat65-D14Rat90) or ACI.FHH-Rf-1+4

 ACI.FHH-(D1Mit18-D1Rat90)/(D14Rat98-D14Hmgc18)/Mcwi or Rf-1a+4_a

 ACI.FHH-(D1Mit18-D1Rat90)/(D3Rat84-D3Rat59)/(D14Mit11-D14Rat33/D14Rat65-D14Rat90) or Rf-1 + 3+4

 ACI.FHH-(D1Mit18-D1Rat90)/(D3Rat6-D3Got149)/(D14Mit11-D14Rat33/D14Rat65-D14Rat90) or Rf-1+3+4_a

 ACI.FHH-(D1Mit18-D1Rat90)/(D3Got102-D3Got149)/(D14Mit11-D14Rat33/D14Rat65-D14Rat90) or Rf-1+3+4_b

 ACI.FHH-(D1Mit18-D1Mit8)/(D14Mit11-D14Hmgc14b/D14Rat65-D14Rat90) or Rf-1B+1

FHH × BN ^{66, 102, 103, 104}

 FHH.1^BNAR⁺

Normal salt or 8.0% NaCl L-NAME

Albuminuria

1, 15, 16, 18

 FHH-1^BN

Proteinuria

1, 14, 15, 16

 FHH-15^BN

Glomerular injury

1, 15, 16, 18

 FHH-16^BN

Blocked medullary tubules (males)

15, 16

 FHH-18^BN

Autoregulation of renal blood flow

1

 FHH-20^BN

 FHH.BN-Rab38

LH × BN ¹²⁷

 LH-13^BN

0.3% NaCl

Proteinuria (may depend on higher BP)

13

 BN-13^LH

MWF × SHR ^{138, 139, 140, 142, 143, 144}

 MWF-6^SHR

0.2% NaCl

Albuminuria

6, 8, 6+8

 MWF-8^SHR

Total nephron number

6, 6+8

 MWF-6^SHR8^SHR

Renal interstitial fibrosis

6, 8 (females)

 SHR-6^MWF

Glomerulosclerosis

6, 6+8

 SHR-8^MWF

Tubulointerstitial damage

6, 8

Podocyte alterations

6, 8, 6+8

SBH × SBN ^{150, 152}

 SBH.1^SBN

Normal diet

Proteinuria

1, 2, 17, 20

 SBH.2^SBN

 SBH.17^SBN

 SBH.20^SBN

 SBH.X^SBN

SHR × BN ¹⁷⁰

 SHR.BN-D1Mit3/Igf2

1%NaCl/0.2% KCl, DOCA

Renal damage such as proteinuria and glomerular injury

1

SHRSP × SHR ^{176, 185}

 SHRSPwch1.0

1% NaCl, stroke-permissive diet

Albuminuria

1

 SHRSP.WKY-(D1Rat44-D1Arb21) or SHRSPwch1.5

Glomerulosclerosis

1

 SHRSP.WKY-(Apbb1-D1Arb21) or SHRSPwch1.8

 SHRSP.WKY-(D1Mgh5-D1Rat44) or SHRSPwch1.9

 SHRSP.WKY-(D1Mgh5-D1Wox29) or SHRSPwch1.11

SS × SHR ^{52, 54, 61, 63, 64, 65}

 S.SHR(2)

0.3% or 2% NaCl

Proteinuria/albuminuria

2, 6 (QTL2), 8, 9, 13

 S.SHR(6)

Glomerular injury

2, 8

 S.SHR(8)

Tubular and interstitial injury

2, 8, 13

 S.SHR(9) × 4A

Fibrosis

2, 8, 13

 S.SHR(9) × 2B

 S.SHR(11)

 S.SHR(13)

SS × SHR ^{48, 49, 53}

 SS-19^SHR

0.2% or

Proteinuria

19

4% NaCl

Albuminuria

19

SS × BN ^{55, 62, 66, 67, 68, 69, 73}

 SS- × BN

0.4% or 4% or 8% NaCl

Proteinuria/albuminuria (m)

1, 5–8, 11, 13, 16, 18, Y

Proteinuria/albuminuria (w)

1–2, 4–14, 16, 18–20

Structural glomerular injury

1

Medullary interstitial fibrosis

13

Tubular necrosis

13

Glomerulosclerosis

13