Table 2 Associations between changes in serum aldosterone and changes in obesity-related factors over the course of the study

From: Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults

Independent variable (change from baseline)

Percent change in aldosterone associated with one-unit change in independent variable (95% CI)

P-valuea

Anthropometric measures

 Weight (%)

0.029 (−0.50, 0.56)

0.92

 BMI (kg m−2)

−0.007 (−1.60, 1.61)

0.99

 Waist circumference (cm)

0.12 (−0.45, 0.69)

0.69

Serum measures

 Insulin (μU ml−1)

1.41 (0.64, 2.19)

0.0005

 CRP (mg l−1)

2.33 (1.11, 3.56)

0.0002

 Leptin (ng ml−1)

0.62 (0.21, 1.04)

0.003

 Adiponectin (μg ml−1)

−1.98 (−3.01, −0.94)

0.0002

 Ghrelin (pg ml−1)

0.004 (−0.01, 0.01)

0.42

Cardiac measures

 Heart rate (beats per min)

0.91 (0.36, 1.47)

0.001

 Log sitting cardiac sympathovagal balance

11.40 (5.04, 18.15)

0.0004

CT adiposity measures

 Abdominal visceral fat area (cm2)

0.12 (−0.10, 0.34)

0.28

 Abdominal subcutaneous fat area (cm2)

0.04 (−0.04, 0.12)

0.29

 Thigh intermuscular fat area (cm2)

2.22 (−0.15, 4.66)

0.053

  1. Abbreviations: BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; CT, computed tomography; HOMA-IR, homeostasis model assessment of insulin resistance.
  2. The association with HOMA-IR (P=0.02) was similar to the association with fasting insulin and thus is not shown. Percentage changes in aldosterone for a one-unit change in the independent variable were calculated using the formula 100 × (exp(β)−1), where β was the parameter estimate for the independent variable from the mixed model.
  3. To convert to SI units, use the following conversion factors: insulin, 6.945; CRP, 9.524; leptin, 0.0625; ghrelin, 0.296.
  4. aP-values are from linear-mixed models for log aldosterone (pg ml−1) that included baseline age, sex, race (black/non-black), intervention arm, time since baseline, and baseline and within-subject changes in 24-h urinary sodium and potassium excretion, and baseline and within-subject changes in the specified independent variable.
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