Figure 4 | Hypertension Research

Figure 4

From: Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine–induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats

Figure 4

The ant-fibrotic effect of ibandronate is mediated through the inhibition of farnesylated proteins. Quiescent VSMCs from SHR were pre-incubated with ibandronate (10 μM), GGTI-286 (10 μM) or FTI-276 (10 μM) for 2 h and then incubated with or without NE (0.1 μM) for 24 h. Some cells were also incubated with GGOH (30 μM), FOH (30 μM) 1 h before the addition of the Iban. Results of total CTGF production were obtained from densitometric analysis and expressed as ratio CTGF/GAPDH as n-fold over control. Figure shows in top panel a representative Western blot and in bottom data total CTGF production as means±s.e.m. of 3 independent experiments. The ratio of CTGF is set to ‘1’ for SHR control group. *P<0.05 vs control, #P<0.05 vs NE, +P<0.05 vs NE+Iban.

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