Figure 5 | Hypertension Research

Figure 5

From: Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine–induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats

Figure 5

Ibandronate diminishes Ras activation in NE–treated SHR-VSMCs. Cells were pretreated for 24 h with Iban 10 μM and then stimulated with NE 0.1 μM for 30 min. Ras activity was determined by pull down assays. Figure shows in top panel a representative Western blot and in bottom as means±s.e.m. of 3 independent experiments. As loading control Ras and GAPDH expression levels were evaluated in total cell lysates. The ratio of active Ras is set to ‘1’ for SHR control group. **P<0.01 vs control, ##P<0.01 vs NE.

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