Figure 5 | Hypertension Research

Figure 5

From: Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats

Figure 5

Macrophage infiltration as well as expression of MCP-1 and osteopontin genes in the left ventricle of rats in the five experimental groups at 11 weeks of age. (a) Immunohistochemical staining for the monocyte-macrophage marker CD68. Scale bars, 100 μm. (b) Density of CD68-positive cells in the LV myocardium as determined from sections similar to those in (a). (c, d) Quantitative RT-PCR analysis of MCP-1 and osteopontin mRNAs, respectively. The amount of each mRNA was normalized by that of GAPDH mRNA and then expressed relative to the mean value for the CONT group. Data in (b) through (d) are means±s.e.m. (n=6, 6, 11, 11 and 11 rats for the CONT, LVH, Val, VAml and VCil groups, respectively). *P<0.05 vs. CONT group; †P<0.05 vs. LVH group; ‡P<0.05 vs. Val group; §P<0.05 vs. VAml group.

Back to article page