Figure 4 | Hypertension Research

Figure 4

From: Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition

Figure 4

Histological examination of coronary arteries from rats treated with l-NAME (C+L) (a–d) or enalapril followed by l-NAME (E+L) (e–h) for 0, 3, 7 and 10 days. Vessels displayed normal histological features in both C+L and E+L at day 0. In both treatment groups, there was evidence of injury as early as day 3 that was characterized by loss of nuclear staining in the medial wall and increased cellular infiltrate surrounding the vessel (b, f, insets). This damage progressed in arteries from both treatment groups over the course of 10 days. Representative sections stained with Hematoxylin and Eosin, × 200 magnification, insets: × 400 magnification. A full color version of this figure is available at Hypertension Research journal online.

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