Table 1 Impact of prior enalapril treatment and l-NAME on systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP)

From: Time course of cardiac inflammation during nitric oxide synthase inhibition in SHR: impact of prior transient ACE inhibition

 

SBP

SBP % change from day 0

DBP

DBP % change from day 0

Pulse pressure

PP % change from day 0

C+L0

172±3.1

—

123±3.4

—

49±5.3

—

C+L3

216±5.6*

26±2.5

156±6.2*

27±3.2

60±6.0*

26±4.2

C+L7

210±8.9*

22±3.9

155±7.8*

26±4.6

55±6.1*

12±3.3

C+L10

226±7.3*

31±3.7

176±8.6*

43±5.6

49±5.6

7±2.8

E+L0

145±3.0‡

—

103±3.6‡

—

41±4.6

—

E+L3

177±4.4†‡

22±1.8

133±3.6†‡

29±2.3

44±5.4

6±6.0‡

E+L7

171±5.8†‡

18±2.8

129±4.7†‡

25±5.2

42±4.5

3±4.8

E+L10

193±7.5†‡

33±3.8

149±5.2†‡

46±6.6

44±5.4

8±5.8

  1. Abbreviations: ANOVA, analysis of variance; l-NAME, l-arginine methyl ester.
  2. Values are presented as mean±s.e.m. SBP: two-way ANOVA: pre-treatment P<0.05, time P<0.05, interaction P=0.23; DBP: two-way ANOVA: pre-treatment P<0.05, time P<0.05, interaction P=0.66. PP: two-way ANOVA: time P<0.05, interaction P<0.05. Bonferroni post-test following repeated measures two-way ANOVA: *P<0.05 vs. C+L0, †P<0.05 vs. E+L0, ‡P<0.05 vs. age matched C+L.
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