Figure 3 | Hypertension Research

Figure 3

From: Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks

Figure 3

(Top) Changes from baseline (mm Hg) in office BP measurements (OBPM), 48 h awake (active span) and asleep (nighttime resting span) systolic blood pressure (SBP) means by 6 mg day−1 spirapril ingested upon awakening or at bedtime in patients with grade 1–2 essential hypertension assessed by 48 h ABPM before and after 12 weeks of timed treatment. Probability values are shown for comparison of effects between the two treatment-time patient groups. (Bottom) Changes from baseline (mm Hg) during the 24 h in SBP after treatment with 6 mg day−1 spirapril ingested either upon awakening or at bedtime. *P<0.05 in BP reduction between the two treatment-time groups (updated from reference 72). A full color version of this figure is available at the Hypertension Research journal online.

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