Figure 5

Renal NADPH oxidase activity in hD5^WT and hD5^F173L transgenic mice. NADPH oxidase activity, measured by lucigenin chemiluminescence, in kidney membranes from hD5^WT and hD5^F173L mice on a normal NaCl (0.8% NaCl) and high NaCl (4% NaCl) diets for 14 and 15 days, respectively, and treated with candesartan (1 mg kg⁻¹ body weight per day) for 10 days. Results are expressed as light units (U) per μg protein per min (n=6, *P<0.05 vs. normal salt; ^#P<0.05 vs. hD5^WT normal salt; ^‡P<0.05 vs. hD5^F173L high salt, t-test).