Table 2 Effect of administration of Ang II and antihypertensive drugs on body weight and systolic blood pressure

From: Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse

 

Body weight (g)

SBP (mmHg)

Saline

19.1±1.1

83.6±2.9

Ang II

18. 9±0.7

153.1±8.0**

Ang II+olm 0.5 mg

20.0±0.9

93.5±4.6††

Ang II+olm 1 mg

20.4±1.2

88.6±3.6††

Ang II+olm 3 mg

20.0±1.0

77.3±3.9††

Ang II+hyd 10 mg

19.3±1.3

84.5±6.1††

  1. Abbreviations: Ang II, Angiotensin II; SBP, systolic blood pressure.
  2. Saline; rats infused by saline, Ang II; rats infused by Ang II (1000 ng kg−1 min−1), Ang II+olm 0.5 mg; rats infused by Ang II (1000 ng kg−1 min−1) and 0.5 mg kg−1 per day of olmesartan, Ang II+olm 1 mg; rats infused by Ang II (1000 ng kg−1 min−1) and 1 mg kg−1 per day of olmesartan, Ang II+olm 3 mg; rats infused by Ang II (1000 ng kg−1 min−1) and 3 mg kg−1 per day of olmesartan, Ang II+hyd; rats infused by Ang II (1000 ng kg−1 min−1) and 10 mg kg−1 per day of hydralazine. N=5 per group.
  3. **P<0.01 vs. Saline, ††P<0.01 vs Ang II.
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