Table 1 Baseline demographic and clinical characteristics of HL and LL controls and patients

From: CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes

 

HLs

LLs

Parameters

NHLs

HHLs

 

NLLs

HLLs

 

n

245

241

P-value

935

545

P-value

Gender

Male

225 (92%)

215 (89%)

 

836 (90%)

495 (91%)

 

Female

20 (8%)

26 (11%)

 

99 (10%)

50 (9%)

 

Clinical characteristics

Age (year)

47.9±12.0

48.8±8.1

NS

46.6.0±12.7

46.5±12.3

NS

BMI (kg m−2)

22.0±5.6

23.0±6.3

NS

23.7±3.7

24.5±2.9

NS

SBP (mm Hg)

115.4±9.7

156.5±19.3

<0.0001

115.6±7.0

159.8±16.8

<0.0001

DBP (mm Hg)

72.3±7.6

96.8±12.7

<0.0001

75.5±4.8

96.2±7.7

<0.0001

MAP (mm Hg)

86.8±7.4

116.5±12.7

<0.0001

88.8±4.9

117.4±9.6

<0.0001

Biochemical parameters

Total cholesterol, mmol l−1

2.9±0.7

3.0±1.1

NS

Triglyceride, mmol l−1

1.2±0.4

1.2±0.5

NS

Uric acid, mg dl−1

4.7±1.0

4.7±1.7

NS

Glucose, mg dl−1

99.5±21.0

101.0±22.0

NS

Proteinurea

Nil

Nil

Nil

Nil

Specific biochemical parameters

8-isoPGF2α (pg ml−1)

3.3±0.9

5.8±1.3

<0.0001

2.3±0.6

4.8±0.8

<0.0001

Catalase (U ml−1)

29.7±8.9

16.5±4.8

<0.0001

35.8±9.2

25.9±8.4

<0.0001

Life style/history

Diet (nonveg)

12%

23%

15%

25%

Family history (HT)

None

73%

None

75%

Alcohol

None

None

6%

10%

Smoking history

None

None

9%

12%

  1. Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; HLs, high-landers; HHLs, hypertensive HLs; HLLs, hypertensive LLs; HT, hypertension; LLs, low-landers; MAP, mean arterial pressure; n, number of subjects; NHLs, normotensive HLs; NLLs, normotensive LLs; SBP, systolic blood pressure.
  2. Data are presented as mean±s.d.