Table 2 Genotype and allele distribution of the CYBA polymorphisms in HL and LL controls and patients

From: CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes

  

HLs, distribution (%)

Biostatistics

LLs, distribution (%)

Biostatistics

SNP/rsID

Genotypes/alleles

NHLs (n=245)

HHLs (n=241)

OR (95% CI)

P-value

NLLs (n=935)

HHLs (n=545)

OR (95% CI)

P-value

rs8854G/A

rs8854GG

237 (97%)

229 (95%)

Reference

—

727 (78%)

397 (73%)

Reference

—

 

rs8854GA

08 (3%)

11 (5%)

1.50 (0.59–3.84)

0.393

196 (21%)

130 (24%)

1.33 (1.00–1.75)

0.047

 

rs8854AA

00 (0%)

01 (0%)

—

0.457

12 (1%)

18 (3%)

2.72 (1.19–6.21)

0.018

 

rs8854AA+GA (Dominant model)

08 (3%)

12 (5%)

1.62 (0.65–4.08)

0.303

208 (23%)

148 (27%)

1.41 (1.08–1.84)

0.012

 

rs8854G

482 (98%)

469 (97%)

Reference

—

1650 (88%)

924 (85%)

Reference

—

 

rs8854A

08 (2%)

13 (3%)

1.72 (0.70–4.22)

0.234

220 (12%)

166 (15%)

1.43 (1.12–1.81)

0.004

rs9932581A/G

rs9932581AA

71 (29%)

50 (21%)

Reference

—

213 (23%)

70 (13%)

Reference

—

 

rs9932581GA

115 (47%)

121 (50%)

1.53 (0.98–2.39)

0.064

444 (47%)

285 (52%)

1.95 (1.40–2.72)

<0.001

 

rs9932581GG

60 (24%)

70 (29%)

1.67 (1.00–2.77)

0.047

278 (30%)

190 (35%)

2.12 (1.49–3.02)

<0.001

 

rs9932581GG+GA (Dominant model)

71 (71%)

191 (79%)

1.58 (1.03–2.40)

0.034

722 (77%)

475 (87%)

2.01 (1.47–2.76)

<0.001

 

rs9932581A

257 (52%)

221 (46%)

Reference

—

870 (47%)

425 (39%)

Reference

—

 

rs9932581G

235 (48%)

261 (54%)

1.30 (1.00–1.67)

0.047

1000 (53%)

665 (61%)

1.38 (1.17–1.63)

<0.001

rs4673T/C

rs4673TT

15 (6%)

08 (3%)

Reference

—

181 (19%)

70 (13%)

Reference

—

 

rs4673TC

70 (29%)

58 (24%)

1.56 (0.61–3.94)

0.352

408 (44%)

225 (41%)

1.58 (1.12–2.23)

0.010

 

rs4673CC

160 (65%)

175 (73%)

2.16 (0.89–5.26)

0.090

346 (37%)

250 (46%)

2.00 (1.41–2.83)

<0.001

 

rs4673CC+TC (Dominant model)

230 (94%)

233 (97%)

1.96 (0.81–4.73)

0.135

754 (81%)

475 (87%)

1.77 (1.28–2.45)

0.001

 

rs4673T

100 (20%)

74 (15%)

Reference

—

770 (41%)

365 (33%)

Reference

—

 

rs4673C

390 (80%)

408 (85%)

1.47 (1.05–2.06)

0.024

1100 (59%)

725 (67%)

1.42 (1.20–1.68)

<0.001

  1. Abbreviations: HLs, high-landers; HHLs, hypertensive HLs; HLLs, hypertensive LLs; LLs, low-landers; n, number subjects; NHLs, normotensive HLs; NLLs, normotensive LLs; OR, odds ratio. P and OR were calculated using multivariate logistic regression analysis after adjustment for age, gender, body-mass index, smoking, alcohol, TG and cholesterol.
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