Table 3 Distribution of CYBA haplotypes between controls and patients of HLs and LLs

From: CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes

 

HLs, distribution (%)

Biostatistics

LLs, distribution (%)

Biostatistics

Haplotypes

NHLs

HHLs

χ 2

P-value

OR (95%CI)

NLLs

HLLs

χ 2

P-value

OR (95%CI)

rs8854A/ rs9932581G/rs4673C

06 (1%)

13 (3%)

2.9

0.090

2.3 (0.9–6.2)

162 (9%)

139 (13%)

13.5

0.0002

1.6 (1.3–2.1)

rs8854G/ rs9932581A/rs4673C

178 (36%)

178 (37%)

0.04

0.845

1.0 (0.8–1.3)

354 (19%)

193 (18%)

0.5

0.472

0.9 (0.7–1.1)

rs8854G/ rs9932581A/rs4673T

76 (16%)

43 (9%)

10.3

0.001

0.5 (0.3–0.8)

474 (25%)

217 (20%)

10.1

0.001

0.7 (0.6–0.9)

rs8854G/ rs9932581G/rs4673C

205 (42%)

217 (45%)

1.2

0.265

1.2 (0.9–1.5)

549 (29%)

380 (35%)

7.5

0.006

1.3 (1.1–1.5)

rs8854G/ rs9932581G/rs4673T

23 (5%)

31 (6%)

1.0

0.313

1.3 (0.8–2.3)

273 (15%)

134 (12%)

3.3

0.071

0.8 (0.6–1.0)

  1. Abbreviations: HLs, high-landers; HHLs, hypertensive HLs; HLLs, hypertensive LLs; LLs, low-landers; n, number subjects; NHLs, normotensive HLs; NLLs, normotensive LLs; OR, odds ratio; χ2, Chi square value. P-values are obtained by permutation test for each haplotype frequency compared between the two groups. χ2 and OR were calculated using multivariate logistic regression analysis after adjustment for age, gender, body mass index, smoking, alcohol, TG and cholesterol.
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