Figure 4 | Hypertension Research

Figure 4

From: Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life

Figure 4

(a) Differential effects of excess cortisol and aldosterone on AGT transcription in visceral adipose tissue. A hypothetical set of interactions between DNA-binding proteins and the AGT promoter is shown. (b) Positive feedback loop of the renin–angiotensin–aldosterone system in human visceral adipose tissue. Ang, angiotensin; APA, aldosterone-producing adenoma; CEBP, CCAAT/enhancer binding protein; CS, Cushing syndrome; GR, glucocorticoid receptor; MR, mineralocorticoid receptor; NFA, non-functioning adenoma; RNA pol II, RNA polymerase II; TSS, transcription start site. A full color version of this figure is available at the Hypertension Research journal online.

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