Figure 5 | Hypertension Research

Figure 5

From: Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influenced by various stimuli experienced in daily life

Figure 5

(a) Gene expression phenotype conversion. Stimulatory signals switch the gene expression phenotype from an inactive to an active state within a tissue. Following stimulation, the gene expression phenotype is gradually restored to its former state. (b) Schematic representation of dynamic changes in DNA methylation patterns. Stimulation can induce DNA demethylation. DNA remethylation takes place following stimulus removal. The degree of changes in DNA methylation depends on local chromatin structure. RNA pol II, RNA polymerase II; TF, transcription factor; TFBS, transcription factor-binding site. A full color version of this figure is available at the Hypertension Research journal online.

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