Table 5 Weighted mean differences in pulse pressure and heart rate between the ARB treatment and control groups according to the types of drugs taken in both groups
From: The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis
Pulse pressure (mm Hg) | Heart rate (beats per minute) | |||||
|---|---|---|---|---|---|---|
Groups | Studies (n) | WMD; 95% CI; P | I2 (P) | Studies (n) | WMD; 95% CI; P | I2 (P) |
Overall | 28 | −0.45; −1.41 to 0.51; 0.359 | 44.0% (0.007) | 17 | 1.34; −0.57 to 3.26; 0.169 | 74.7% (0.000) |
By drugs in treatment group | ||||||
Valsartan | 13 | −0.58; −2.26 to 1.10; 0.501 | 70.2% (0.000) | 8 | 0.94; −0.30 to 2.18; 0.138 | 12.2% (0.335) |
Telmisartan | 4 | −0.10; −2.35 to 2.16; 0.934 | 0.0% (0.706) | 2 | 0.98; −3.62 to 5.58; 0.675 | 0.0% (0.766) |
Losartan | 3 | 0.45; −2.35 to 3.26; 0.751 | 22.9% 90.273) | 4 | 6.66; 0.77 to 12.55; 0.027 | 89.8% (0.000) |
Candesartan | 5 | −0.36; −2.87 to 2.16; 0.782 | 0.0% 90.603) | 3 | −2.81; −5.85 to 0.23; 0.070 | 0.0% (0.755) |
Irbesartan | 3 | −1.27; −3.46 to 0.93; 0.257 | 0.0% (0.866) | |||
By drugs in control group | ||||||
ACEI | 6 | −1.27; −3.17 to 0.63; 0.189 | 0.0% (0.516) | 4 | 0.41; −1.51 to 2.32; 0.675 | 0.0% (0.786) |
Placebo | 3 | −2.88; −6.40 to 0.64; 0.109 | 0.0% (0.869) | |||
Diuretics | 2 | 0.95; −2.62 to 4.52; 0.603 | 0.0% (0.432) | |||
CCB | 12 | −0.45; −1.91 to 1.0; 0.540 | 68.8% (0.000) | 7 | 1.00; −0.39 to 2.39; 0.159 | 20.8% (0.271) |
Beta blocker | 3 | 8.47; 0.87 to 16.08; 0.029 | 87.1% (0.000) | |||
Non-RAS | 4 | 0.77; −1.93 to 3.47; 0.574 | 0.0% (0.563) | |||
