Table 2 Relationship between biomarkers and patient characteristics

	trOPN-N		OPN		MMP-9		CRP		S100B		D-dimer
	ρ	P-value	ρ	P-value	ρ	P-value	ρ	P-value	ρ	P-value	ρ	P-value
Clinical background
Sex^a	0.05	0.73	−0.11	0.39	0.23	0.08	−0.20	0.16	0.22	0.13	0.09	0.59
Age	0.22	0.09	0.32	0.01	0.07	0.60	0.02	0.91	0.20	0.18	0.48	<0.01
Symptom duration	0.06	0.63	0.10	0.45	0.11	0.42	0.24	0.11	−0.10	0.50	0.01	0.93
Infarct size	0.11	0.51	0.00	0.99	0.11	0.51	0.27	0.16	0.11	0.51	0.44	0.03
Hypertension^a	0.19	0.16	0.07	0.63	0.15	0.27	−0.30	0.86	0.25	0.10	0.01	0.96
Diabetes^a	0.33	0.01	0.22	0.10	−0.01	0.98	0.01	0.98	0.05	0.76	0.17	0.30
Dyslipidemia^a	0.23	0.09	−0.09	0.54	0.08	0.55	0.09	0.57	0.08	0.58	−0.11	0.51
Current smoker^a	−0.22	0.13	−0.13	0.39	−0.04	0.77	−0.18	0.25	−0.28	0.07	−0.03	0.87
Sum of risk factors^b	0.27	0.08	0.17	0.27	−0.20	0.21	0.04	0.79	−0.06	0.70	0.18	0.33
Anti-platelet drug^a	0.21	0.11	0.10	0.47	−0.12	0.37	0.07	0.61	0.17	0.24	0.11	0.53
Anti-hypertensive drug^a	0.26	0.06	0.14	0.31	0.13	0.36	0.09	0.55	0.32	0.03	0.11	0.52
Statin^a	0.33	0.02	0.11	0.45	0.02	0.86	0.18	0.20	0.17	0.27	−0.08	0.63
NIHSS score
On admission	0.09	0.55	0.19	0.18	−0.03	0.98	0.26	0.09	0.31	0.04	0.38	0.02
At discharge	0.06	0.72	0.15	0.38	0.03	0.84	−0.02	0.92	0.04	0.82	0.07	0.74
Blood tests
Serum creatinine	0.23	0.10	0.31	0.02	−0.18	0.19	0.17	0.23	0.12	0.42	0.08	0.63
trOPN-N	1.00	—	0.41	<0.001	−0.05	0.69	0.07	0.63	0.35	0.01	0.45	<0.01
OPN	—	—	1.00	—	−0.26	0.04	0.11	0.45	0.09	0.55	0.53	<0.01
MMP-9	—	—	—	—	1.00	—	−0.03	0.84	−0.06	0.67	−0.17	0.31
CRP	—	—	—	—	—	—	1.00	—	0.23	0.14	0.10	0.56
S100B	—	—	—	—	—	—	—	—	1.00	—	0.12	0.46

Abbreviations: CRP, C-reactive protein; MMP-9, matrix metalloproteinase 9; NIHSS, National Institutes of Health Stroke Scale; OPN, osteopontin; trOPN-N, thrombin-cleaved osteopontin N-terminal.
Spearman’s rank-order correlations were determined.
^aMale, patients with hypertension, diabetes, dyslipidemia, current smoking and using medicine were stated as 1, and others are 0, respectively.
^bDefinition of sum of risk factors is the same as Table 1.

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