Figure 5
From: Notch activation of Ca2+-sensing receptor mediates hypoxia-induced pulmonary hypertension
The proliferation of freshly isolated pulmonary arterial smooth muscle cells (PASMCs) from the HPH rats is enhanced by Jag-1 and restored to normal levels by DAPT. Summarized data showing the stimulatory effects of Jag-1 on the proliferation of freshly isolated PASMCs from the normal rats (a). Summarized data showing the inhibitory effects of DAPT on the proliferation of freshly isolated PASMCs from the HPH rats (b; **P<0.01, hypoxia+DAPT vs. hypoxia+vehicle; hypoxia+Jag-1 vs. hypoxia+vehicle).
