Table 1 Characteristics of patients with primary aldosteronism and essential hypertension

From: Comparison of left ventricular structure and function in primary aldosteronism and essential hypertension by echocardiography

 

Primary aldosteronism

Essential hypertension

 
 

(n=100)

(n=100)

P-value

Age (years)

49.6±12.4

49.9±11.9

0.87

Sex, male/female, %

58/42

58/42

NS

Body mass index (kg m−2)

25.1±3.4

25.8±3.2

0.16

Hypertension course (years)

10.3±7.0

10.4±10.0

0.94

Systolic blood pressure, clinic (mm Hg)

150±21

152±19

0.50

Diastolic blood pressure, clinic (mm Hg)

88±13

90±14

0.28

Pulse pressure, clinic (mm Hg)

62±15

61±15

0.94

Heart rate, clinic (BPM)

77±12

78±11

0.10

Systolic blood pressure, 24-h (mm Hg)

138±16

135±14

0.10

Diastolic blood pressure, 24-h (mm Hg)

87±9

85±10

0.08

Pulse pressure, 24-h (mm Hg)

51±12

50±12

0.46

Heart rate, 24-h (BPM)

71±9

73±10

0.06

Fasting glucose (mmol l−1)

5.3±1.3

5.5±1.1

0.24

2 h glucose (mmol l−1)

7.6±3.0

7.9±3.5

0.57

Diabetes mellitus, n (%)

17 (17)

23 (23)

0.29

Serum TC (mmol l−1)

4.4±0.9

4.8±0.9

0.001

Serum TG (mmol l−1)

1.7±1.0

2.4±2.1

0.004

HDL-C (mmol l−1)

1.2±0.3

1.2±0.3

0.40

LDL-C (mmol l−1)

2.6±0.7

3.0±0.8

0.005

Uric acid (μmol l−1)

312±96

347±94

0.01

Serum creatinine (μmol l−1)

74±21

81±23

0.02

Urinary aldosterone (μg per 24 h)

22.8±14.3

7.5±6.8

<0.001

Plasma aldosterone (pg ml−1)

346±243

180±107

<0.001

Plasma renin activity (ng ml−1 per h)

0.87±1.04

3.18±2.56

<0.001

lg ARR

2.84±0.64

1.95±0.65

<0.001

Serum potassium (mmol l−1)

3.21±0.43

3.82±0.31

<0.001

Urinary potassium (mmol per 24 h)

63.4±31.8

31.3±12.9

<0.001

Serum sodium (mmol l−1)

141.6±3.5

139.9±3.1

<0.001

Urinary sodium (mmol per 24 h)

148.3±71.9

140.9±69.5

0.47

lg NT-proBNP

1.75±0.46

1.47±0.54

<0.001

Antihypertensive agents history (4 weeks before)

 MR inhibitor, n (%)

29 (29)

3 (3)

<0.001

 CCB, n (%)

86 (86)

81 (81)

0.34

 ACE-I or ARB, n (%)

78 (39)

66 (33)

0.06

 Adrenoceptor blockers, n (%)

10 (10)

3 (3)

0.045

 Beta-blocker, n (%)

40 (40)

35 (35)

0.47

 Diuretic, n (%)

39 (39)

38 (38)

0.88

  1. Abbreviations: ACE-I, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARR, aldosterone/renin ratio; BPM, beats per min; CCB, calcium-channel blocker; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MR, mineralocorticoid receptor; NS, not significant; NT-proBNP, N-terminal pro-brain natriuretic peptide; TC, total cholesterol; TG, triglycerides.
Back to article page