Table 1 General and arterial structural characteristics of first- and third-order mesenteric resistance arteries

From: Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR

 

Vehicle

SOL1

Losartan

Hydralazine

Body weight (g)

353±7

362±8

366±6

356±9

MAP (mmHg)

191±7

172±3

125±5a

113±14a

Diameter 1st order (μm)

373±21

369±17

397±19

398±14

 mCSA (103 μm2)

30±3

26±2

24±3

28±3

 Media-to lumen ratio

0.184±0.014

0.164±0.006

0.144±0.008a

0.150±0.012

 NCC

55±3

47±2

49±1

52±3

Diameter 3rd order (μm)

273±8

282±10

244±10a

288±7

 Active tension (N m–1)b

4.91±0.43

5.55±0.45

4.65±0.22

4.44±0.37

 mCSA (103 μm2)

13±1

14±1

11±1

13±1

 Media-to lumen ratio

0.115±0.005

0.140±0.02

0.109±0.004

0.109±0.004

  1. Abbreviations: MAP, mean arterial pressure; mCSA, cross-sectional area of the media; NA, noradrenaline; NCC, cell count of the media (nuclear profiles).
  2. Results are depicted as mean±s.e.m.
  3. aP<0.05 treatment vs. Vehicle.
  4. bMaximal contractile response induced by NA.
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