Table 3 Comparison of CPET parameters between event and event-free patients with IPAH

From: Sex-specific cardiopulmonary exercise testing parameters as predictors in patients with idiopathic pulmonary arterial hypertension

 

All patients

Male patients

Female patients

 

Event (n=24)

Event-free (n=33)

Event (n=9)

Event-free (n=12)

Event (n=15)

Event-free (n=21)

Exercise capacity parameters

 Peak workload, Watt

67.1±28.6

76.5±29.6

66.9±28.3

87.9±37.3*

58.9±17.3

74.5±27.9

Metabolic parameters

 Peak VO2, ml min−1 kg−1

13.4±3.3

15.7±4.1*

13.8±4.0

15.8±4.7

12.7±2.9

15.6±3.7*

 VO2 at AT, ml min−1 kg−1

9.8±2.2

11.2±2.7

10.4±2.2

11.8±3.0

9.1±1.8

11.0±2.6

Ventilatory parameters

 Peak VCO2, ml min−1

819.3±256.3

993.3±290.1*

889.5±271.0

1077.4±359.6

708.4±163.4aa

969.5±247.7**

 Peak VE, l min−1

45.9±16.8

44.6±10.8

60.3±15.2

49.3±13.0

34.4±7.3

43.2±9.6**

 Peak VO2/VE

17.7±5.2

20.7±4.9*

13.8±4.0

15.80±4.70**

20.4±4.0aa

20.7±5.0

 OUEP, ml l−1

25.4±5.1

29.0±5.4*

23.0±6.0

27.3±4.2

26.6±4.2

29.8±5.6

 OUES, l min−1 log−1

1.0±0.3

1.2±0.4

1.0±0.4

1.4±0.5*

1.0±0.3

1.1±0.3

 Lowest VE/VCO2

49.8±12.4

42.3±9.0*

57.9±15.5

45.5±13.9*

45.7±7.2a

41.3±8.1

Cardiovascular parameters

 Peak O2 pulse, ml per beat

5.4±1.0

6.8±2.1**

5.8±1.3

7.4±2.7

5.1±0.6

6.5±1.6**

 Peak HR, beats per minute

144.0±26.9

139.6±23.6

145.9±32.9

137.7±27.3

139.7±23.4

142.8±22.1

Gas exchange parameters

 Peak PETO2, mm Hg

127.6±6.1

124.1±6.0*

132.3±5.9

125.0±5.7**

124.2±4.4aa

124.1±6.2

 PETO2 at AT, mm Hg

121.5±7.2

117.0±7.7*

126.7±6.0

119.4±5.8*

118.3±6.5

125.9±8.1

 Peak PETCO2, mm Hg

22.1±6.7

27.8±6.7**

17.5±6.9

27.3±5.7**

24.8±5.4a

27.9±7.0

 PETCO2 at AT, mm Hg

25.2±7.1

30.2±6.3**

22.1±8.3

28.6±5.0*

26.6±6.1

30.9±6.6

  1. Abbreviations: AT, anaerobic threshold; CPET, cardiopulmonary exercise testing; HR, heart rate; IPAH, idiopathic pulmonary arterial hypertension; OUEP, oxygen uptake efficiency plateau; OUES, oxygen uptake efficiency slope; PETCO2, end-tidal partial pressure of CO2; PETO2, end-tidal partial pressure of O2; PVR, pulmonary vascular resistance; VCO2, carbon dioxide output; VE, minute ventilation; VO2, oxygen uptake.
  2. *P<0.005 and **P<0.01, event-free vs. event. aP<0.05 and aaP<0.01, event in women vs. event in men.
  3. Values are mean (s.d.) or median (interquartile range).
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