Table 2 Distributions of genotypic and single factor analysis of 29 tag-SNPs in SSH candidate genes

From: Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes

dbSNP

Gene symbol

Genomic position (bp)

Models

Genotype

χ2 test

Minor allele

χ2 test

MAF

PHWE

     

P-value

OR (95% CI)

 

P-value

OR (95% CI)

  

Rs4961

ADD1

2 906 707

Additive

TT vs. TG vs. GG

0.707

—

G

0.443

1.17 (0.79–1.74)

0.45

0.884

   

Dominant

(TT+TG) vs. GG

0.421

1.31 (0.68-2.52)

     
   

Recessive

TT vs. (TG+GG)

0.641

1.16 (0.62–2.18)

     

Rs699

AGT

230 845 794

Additive

TT vs. TC vs. CC

0.371

—

T

0.196

1.35 (0.86–2.14)

0.20

0.521

   

Dominant

(TT+TC) vs. CC

0.285

0.74 (0.42–1.29)

     
   

Recessive

TT vs. (TC+CC)

0.425

0.49 (0.15–1.66)

     

Rs2681472

ATP2B1

90 008 959

Additive

CC vs. CT vs. TT

0.967

—

C

0.866

1.04 (0.69–1.56)

0.34

0.859

   

Dominant

(CC+CT) vs. TT

0.953

0.98 (0.56–1.72)

     
   

Recessive

CC vs. (CT+TT)

0.796

0.90 (0.39–2.05)

     

Rs7961152

BCAT1

24 981 611

Additive

AA vs. AC vs. CC

0.044*

—

A

0.591

1.18 (0.64–2.16)

0.10

0.054

   

Dominant

(AA+AC) vs. CC

0.988

0.10 (0.51–1.96)

     
   

Recessive

AA vs. (AC +CC)

0.034*

5.55 (4.41–6.98)

     

Rs848307

CLCNKA

16 319 232

Additive

TT vs. TC vs. CC

0.472

—

T

0.242

0.77 (0.49–1.20)

0.31

0.541

   

Dominant

(TT+TC) vs. CC

0.221

1.42 (0.81–2.48)

     
   

Recessive

TT vs. (TC+CC)

0.626

1.28 (0.47–3.46)

     

Rs1739843

CLCNKA

16 343 254

Additive

TT vs. TC vs. CC

0.201

—

T

0.069

0.65 (0.41–1.04)

0.31

0.544

   

Dominant

(TT+TC) vs. CC

0.113

1.59 (0.89–2.81)

     
   

Recessive

TT vs. (TC+CC)

0.191

2.22 (0.65–7.58)

     

Rs1010069

CLCNKA

16 352 937

Additive

CC vs. CT vs. TT

0.856

—

C

0.617

0.90 (0.58–1.38)

0.32

0.592

   

Dominant

(CC+CT) vs. TT

0.738

1.10 (0.63–1.92)

     
   

Recessive

CC vs. (CT+TT)

0.596

1.31 (0.48–3.53)

     

Rs1799998

CYP11B2

143 999 600

Additive

CC vs. CT vs. TT

0.107

—

C

0.042*

1.54 (1.02–2.32)

0.26

0.348

   

Dominant

(CC+CT) vs. TT

0.148

0.67 (0.38–1.16)

     
   

Recessive

CC vs. (CT+TT)

0.051

0.46 (0.20–1.02)

     

Rs1126742

CYP4A11

47 398 496

Additive

CC vs. CT vs. TT

0.312

—

C

0.815

0.94 (0.57–1.55)

0.20

0.459

   

Dominant

(CC+CT) vs. TT

0.835

0.94 (0.53–1.67)

     
   

Recessive

CC vs. (CT+TT)

0.321

1.23 (1.17–1.30)

     

Rs1799983

eNOS

150 696 111

Additive

TT vs. TG vs. GG

0.189

—

T

0.239

1.42 (0.79–2.54)

0.10

0.566

   

Dominant

(TT+TG) vs. GG

0.402

0.76 (0.39–1.46)

     
   

Recessive

TT vs. (TG+GG)

0.154

0.22 (0.03–1.58)

     

Rs5351

EDNBR

78 475 313

Additive

GG vs. GA vs. AA

0.560

—

G

0.462

1.16 (0.78–1.73)

0.37

0.866

   

Dominant

(GG+GA) vs. AA

0.804

0.93 (0.53–1.65)

     
   

Recessive

GG vs. (GA+AA)

0.285

0.68 (0.33–1.39)

     

Rs16998073

FGF5

81 184 341

Additive

TT vs. TA vs. AA

0.054

—

T

0.177

0.76 (0.51–1.13)

0.47

0.301

   

Dominant

(TT+TA) vs. AA

0.026*

1.91 (1.08–3.40)

     
   

Recessive

TT vs. (TA+AA)

0.879

0.95 (0.48–1.87)

     

Rs1129649

GNB3

6 948 468

Additive

CC vs. CT vs. TT

0.874

—

C

0.604

1.12 (0.73–1.72)

0.29

0.813

   

Dominant

(CC+CT) vs. TT

0.661

0.88 (0.51–1.54)

     
   

Recessive

CC vs. (CT+TT)

0.689

0.83 (0.32–2.12)

     

Rs1024323

GRK4

3 006 043

Additive

AA vs. AG vs. GG

0.750

—

A

0.647

1.12 (0.69–1.83)

0.18

0.630

   

Dominant

(AA+AG) vs. GG

0.803

0.93 (0.52–1.66)

     
   

Recessive

AA vs. (AG+GG)

0.718

0.60 (0.15–2.31)

     

Rs1801058

GRK4

3 039 150

Additive

CC vs. CT vs. TT

0.654

—

C

0.933

0.98 (0.66–1.46)

0.43

0.259

   

Dominant

(CC+CT) vs. TT

0.578

1.18 (0.66–2.13)

     
   

Recessive

CC vs. (CT+TT)

0.599

0.83 (0.41–1.68)

     

Rs2398162

LOC100132798

96 830 550

Additive

AA vs. AG vs. GG

0.333

—

A

0.179

0.76 (0.50–1.14)

0.40

0.945

   

Dominant

(AA+AG) vs. GG

0.138

1.52 (0.87–2.65)

     
   

Recessive

AA vs. (AG+GG)

0.573

1.26 (0.56–2.84)

     

Rs2288774

NEDD4L

55 983 330

Additive

CC vs. CT vs. TT

0.680

—

C

0.430

1.18 (0.79–1.77)

0.34

0.449

   

Dominant

(CC+CT) vs. TT

0.581

0.85 (0.48–1.51)

     
   

Recessive

CC vs. (CT+TT)

0.414

0.72 (0.32–1.60)

     

Rs4149601

NEDD4L

55 816 791

Additive

AA vs. AG vs. GG

0.625

—

A

0.339

0.75 (0.42–1.35)

0.17

0.835

   

Dominant

(AA+AG) vs. GG

0.339

1.38 (0.71–2.66)

     
   

Recessive

AA vs. (AG+GG)

1.000

1.52 (0.18–12.60)

     

Rs7897633

PRKG1

52 957 721

Additive

AA vs. AC vs. CC

0.041*

—

A

0.012*

1.66 (1.12–2.47)

0.48

0.973

   

Dominant

(AA+AC) vs. CC

0.072

0.52 (0.25–1.07)

     
   

Recessive

AA vs. (AC+CC)

0.023*

0.51 (0.28–0.92)

     

Rs1904694

PRKG1

52 905 494

Additive

GG vs. GA vs. AA

0.007*

—

G

0.003*

1.81 (1.22–2.69)

0.36

0.478

   

Dominant

(GG+GA) vs. AA

0.038*

0.52 (0.28–0.97)

     
   

Recessive

GG vs. (GA+AA)

0.003*

0.37 (0.19–0.73)

     

Rs5735

SCNN1G

23 200 848

Additive

TT vs. TC vs. CC

0.338

—

T

0.414

0.80 (0.46–1.38)

0.18

0.676

   

Dominant

(TT+TC) vs. CC

0.250

1.45 (0.77–2.74)

     
   

Recessive

TT vs. (TC+CC)

0.908

0.72 (0.19–2.71)

     

Rs3790261

SLC24A3

19 560 664

Additive

GG vs. GA vs. AA

0.595

—

G

0.379

0.83 (0.55–1.26)

0.36

0.554

   

Dominant

(GG+GA) vs. AA

0.563

1.18 (0.68–2.06)

     
   

Recessive

GG vs. (GA+AA)

0.331

1.62 (0.61–4.33)

     

Rs434082

SLC8A1

40 485 074

Additive

AA vs. AG vs. GG

0.097

—

A

0.036*

1.68 (1.03–2.74)

0.15

0.727

   

Dominant

(AA+AG) vs. GG

0.032*

0.54 (0.30–0.95)

     
   

Recessive

AA vs. (AG+GG)

0.827

0.55 (0.10–2.91)

     

Rs11893826

SLC8A1

40 564 647

Additive

AA vs. AG vs. GG

0.045*

—

A

0.309

1.26(0.81–1.96)

0.31

0.093

   

Dominant

(AA+AG) vs. GG

0.059

1.72 (0.98–3.03)

     
   

Recessive

AA vs. (AG+GG)

0.311

0.63 (0.25–1.55)

     

Rs1937506

—

68 035 371

Additive

AA vs. AG vs. GG

0.218

—

A

0.359

1.29 (0.75–2.25)

0.12

0.235

   

Dominant

(AA+AG) vs. GG

0.551

0.83 (0.44–1.54)

     
   

Recessive

AA vs. (AG+GG)

0.157

0.22 (0.03–1.60)

     

Rs3754777

STK39

169 015 914

Additive

AA vs. AG vs. GG

0.459

—

A

0.399

1.21 (0.78–1.88)

0.24

0.874

   

Dominant

(AA+AG) vs. GG

0.259

0.73 (0.42–1.27)

     
   

Recessive

AA vs. (AG+GG)

1.000

1.14 (0.32–4.08)

     

Rs6749447

STK39

169 041 386

Additive

TT vs. TG vs. GG

0.523

—

T

0.523

1.12 (0.74–1.68)

0.35

0.464

   

Dominant

(TT+TG) vs. GG

0.995

1.00 (0.57–1.76)

     
   

Recessive

TT vs. (TG+GG)

0.278

0.65 (0.30–1.42)

     

Rs1042714

ADRB2

148 206 473

Additive

GG vs. GC vs. CC

0.004*

—

G

0.001*

2.38 (1.38–4.08)

0.09

0.367

   

Dominant

(GG+GC) vs. CC

0.003*

0.40 (0.22–0.74)

     
   

Recessive

GG vs. (GC+CC)

0.086

0.11 (0.01–1.21)

     

Rs1042713

ADRB2

148 206 440

Additive

GG vs. GA vs. AA

0.204

—

G

0.081

1.45 (0.95–2.20)

0.40

0.884

   

Dominant

(GG+GA) vs. AA

0.097

0.57 (0.29–1.12)

     
   

Recessive

GG vs. (GA+AA)

0.249

0.65 (0.32–1.35)

     
  1. Abbreviations: 95% CI, 95% confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odd ratio; SNP, single-nucleotide polymorphism.
  2. P-values are calculated by χ2.
  3. *P<0.05.
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