Table 1 Patient characteristics by cured and not cured

From: Body mass index and contralateral ratio predict outcome following unilateral adrenalectomy in primary aldosteronism

 

All (n=96)

Cured (n=46)

Not cured (n=50)

P-value (cured vs. not cured)

Age at surgery, years

51±11

47±12

55±10

0.0009

Male, n (%)

40 (41.7)

13 (28.3)

27 (54.0)

0.0106

BMI, kg m−2

23.3±3.5

21.8±3.4

24.6±3.0

<0.0001

Complication of DM, n (%)

4 (4.2)

2 (4.4)

2 (4.0)

0.9321

Complication of DL, n (%)

18 (18.8)

5 (10.9)

13 (26.0)

0.0587

Past history of CVD, n (%)

5 (5.2)

2 (4.4)

3 (6.0)

0.7159

Smoking, n (%)

32 (33.7)

12 (26.1)

20 (40.8)

0.129

Alcohol, n (%)

32 (33.7)

15 (32.6)

17 (34.7)

0.8298

Family history of HTN, n (%)

67 (69.8)

33 (71.7)

34 (68.0)

0.6902

Preoperative systolic BP, mm Hg

140±17

138±13

142±21

0.3419

Preoperative diastolic BP, mm Hg

85±12

84±11

86±13

0.5771

Number of antihypertensive medications

1.3±0.9

1.1±0.7

1.5±1.0

0.0338

K+ supplementation, n (%)

47 (49.0)

25 (54.4)

22 (44.0)

0.311

MRB medication, n (%)

65 (67.7)

29 (63.0)

36 (72.0)

0.3485

K+, mEq l−1

3.2±0.5

3.2±0.4

3.2±0.6

0.5027

UA, mg dl−1

4.9±1.4

4.4±1.1

5.5±1.4

<0.0001

eGFR, ml min−1 per 1.73 m2

78.2±20.8

81.7±16.0

75.0±24.1

0.1172

PAC, pg ml−1

362±269

338±179

384±332

0.3999

PRA, ng ml−1 h−1

0.3±0.4

0.3±0.2

0.3±0.5

0.3729

ARR

2545±4331

2727.3±5522.6

2374.7±2843.2

0.6939

Urinary aldosterone excretion, μg per day

24.4±15.2

25±16

23±14

0.6102

Urinary Na+/K+ excretion

3.0±1.5

2.9±1.6

3.1±1.3

0.4891

Tumor diameter, mm

14.6±5.4

14.3±4.6

15.0±6.2

0.5019

Pathologic diagnosis

 Cortical adenoma, n (%)

76 (79)

37 (80.4)

38 (79.8)

0.8784

 Nodular hyperplasia, n (%)

4 (4)

0 (0)

4 (8.3)

0.0454

 Cortical adenoma + hyperplasia, n (%)

16 (17)

9 (19.6)

6 (12.5)

0.3498

 Postoperative systolic BP, mm Hg

125±12

122±13

127±11

0.0375

 Postoperative diastolic BP, mm Hg

79±8

78±9

79±8

0.7381

 Postoperative antihypertensive medications

0.7±0.8

0.0±0.0

1.3±0.6

<0.0001

  1. Abbreviations: ARR, aldosterone/renin ratio; BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; DM, diabetes mellitus; DL, dyslipidemia; eGFR, estimated glomerular filtration ratio; HTN, hypertension; MRB, mineralocorticoid receptor; PAC, plasma aldosterone concentration; PRA, plasma renin activity; UA, uric acid.
  2. Data are mean±s.d. for continuous variables, and number (percent) for categorical variables. Bold values are those found to be significant; P-value <0.05.
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