Table 1 Sexual functioning after combined RP and RT
From: Counseling patients about sexual health when considering post-prostatectomy radiation treatment
Study | Prospective vs retrospective | Validated instrument | Pre-op assessment | Pre-RT assessment | Post-RT assessment | Patient or physician reported outcome | Findings |
|---|---|---|---|---|---|---|---|
South West Oncology Group (SWOG, Moinpour et al.31) | Prospective randomized adjuvant vs observation N=107 RP N=110 RP+RT | Partly Rand Medical Outcome Study Short Form-20 Scale; Rand Medical Outcome Study Short Form-36 Scale with added genitourinary items | No | Yes | Yes | Physician | No significant difference in sexual dysfunction between RP only and RP and RT groups (12-year follow-up) |
European Organization for the Research and Treatment of Cancer (EORTC, Scalliet et al.40) | Prospective randomized adjuvant vs observation N=502 RP N=503 RP+RT | Partly Quality of Life Questionnaire —C-30 and an ad hoc prostate treatment-specific questionnaire developed for the study | No | No | Yes | Patient | No significant difference in sexual dysfunction between RP only and RP and RT groups (5 years) |
Hu et al.28 | Prospective non-randomized salvage RT vs observation N=1220 RP N=69 RP+RT | Yes Rand Medical Outcomes Study Short Form-36; UCLA-Prostate Cancer Index | Yes | No | Yes | Patient | Sexual dysfunction was significantly greater in men with salvage RT (up to 2 years after RT, up to 3 years after RP) |
Formenti et al.29 | Retrospective adjuvant RT vs observation N=189 RP N=105 RP+RT | No Clinical interviews pre-operatively, 1 and 3 years postoperatively | Yes | No | Yes | Patient | No significant difference in sexual dysfunction between RP only and RP and RT groups (3+ years) |
Radiotherapy and Androgen Deprivation In Combination After Local Surgery (Parker41) | Prospective Adjuvant vs salvage RT Accruing patients | Yes EuroQuality of Life Questionnaire International Continence Society–Males-SF Rand Medical Outcome Study Short Form-12 Scale; Vaizey Incontinence Questionnaire International Index of Erectile Functioning-5 | No | Yes | Yes | Patient | Results pending |
