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Abnormal postprandial PYY response in insulin sensitive nondiabetic subjects with a strong family history of type 2 diabetes

International Journal of Obesity volume 32, pages 943–948 (2008)Cite this article

Abstract

Objective:

Gut-derived hormone peptide YY (PYY) is low in subjects with obesity and type 2 diabetes (T2D). However, it is unknown whether this is a primary defect or a consequence of metabolic disturbances. In this study, we aimed to assess whether low fasting and postprandial PYY secretion is an early defect, potentially promoting the development of obesity and T2D, and whether it is modified by macronutrient content.

Design:

Prospective cross-sectional cohort study.

Subjects:

Nine individuals with a strong family history of T2D (REL) and seven age and adiposity matched individuals with no family history of T2D (CON).

Interventions:

Metabolic studies including hyperinsulinemic-euglycemic clamp, dual X-ray absorptiometry and two meal tests containing 1000 kcal with an either high fat (76%) or high carbohydrate (76%) content.

Main outcome measures:

Fasting and postprandial PYY levels were measured and analyzed for potential correlations with markers for adiposity and insulin resistance.

Results:

Insulin sensitivity was not different between REL and CON. Fasting glucose, insulin, triglycerides and PYY were also not different between groups. However, the postprandial incremental area under curve (AUC) of PYY was significantly lower in REL after the high carbohydrate (HCHO) meal (+27.3 vs +60.6% increase from baseline, P=0.038). The AUC of insulin during HCHO meal correlated negatively with both AUC and fasting level of PYY (r=−0.58 and −0.60, respectively, P<0.05).

Conclusions:

A blunted postprandial PYY secretion is observed in a very early stage in the development of T2D in genetically susceptible individuals. This defect precedes the presence of insulin resistance and adiposity, and could therefore predispose to the development of T2D.

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Acknowledgements

We thank the staff of the Garvan Clinical Research Facility. We also particularly thank all the volunteers who participated in the study. This study was supported by NHMRC Postgraduate Scholarship (AV), Rebecca L Cooper Foundation (SG), Danish Medical Council Research Grant (SG), NHMRC Biomedical Fellowship (LKH). All researchers were independent from the funding bodies, which did not have a role in the decision of study design, data collection and analysis and submission for publication.

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Authors and Affiliations

  1. Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    A Viardot, L K Heilbronn & L V Campbell

  2. Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    H Herzog

  3. Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark

    S Gregersen

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  1. A Viardot
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  2. L K Heilbronn
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  3. H Herzog
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  4. S Gregersen
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  5. L V Campbell
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Correspondence to A Viardot.

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Viardot, A., Heilbronn, L., Herzog, H. et al. Abnormal postprandial PYY response in insulin sensitive nondiabetic subjects with a strong family history of type 2 diabetes. Int J Obes 32, 943–948 (2008). https://doi.org/10.1038/ijo.2008.24

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