Table 2 OR for overweight and obesity depending on MGAT1genotypes

From: Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

ULSAM

N

Genotype, n (%)

Allele frequency (%)

HWE

OR (95% CI)

P*

  

G1

G2

G3

A1

A2

   

 rs12517906 G>A

Normal weight

540

409 (76)

123 (23)

8 (1)

86.9

13.1

0.509

  

Overweight

575

431 (75)

136 (24)

8 (1)

86.2

13.8

0.585

1.068 (0.827–1.379)

0.614

Obese

52

37 (71)

15 (29)

0 (0)

85.6

14.4

0.574

1.132 (0.636–2.014)

0.673

 rs12186500 G>A

Normal weight

519

208 (40)

251 (48)

60 (12)

63.0

37.0

0.251

  

Overweight

556

201 (36)

286 (51)

69 (13)

61.9

38.1

0.058

1.152 (0.956–1.389)

0.137

Obese

52

12 (23)

29 (56)

11 (21)

49.0

51.0

0.578

1.892 (1.237–2.895)

0.003

 rs6886113 T>C

Normal weight

532

331 (62)

179 (34)

22 (4)

79.9

20.1

0.794

  

Overweight

565

360 (64)

178 (31)

27 (5)

79.0

21.0

0.438

1.014 (0.821–1.251)

0.899

Obese

52

32 (62)

14 (27)

6 (11)

75.0

25.0

0.058

1.275 (0.795–2.043)

0.313

 rs1021001 C>G

Normal weight

540

417 (77)

114 (21)

9 (2)

87.7

12.3

0.687

  

Overweight

575

441 (77)

125 (22)

9 (1)

87.6

12.4

1.000

1.078 (0.834–1.394)

0.566

Obese

52

32 (61)

17 (33)

3 (6)

77.9

22.1

0.962

2.102 (1.280–3.455)

0.003

 rs4285184 A>G

Normal weight

540

346 (64)

167 (31)

27 (5)

78.6

21.4

0.236

  

Overweight

572

351 (61)

187 (33)

34 (6)

77.7

22.3

0.184

1.177 (0.962–1.441)

0.114

Obese

52

25 (48)

23 (44)

4 (8)

70.2

29.8

1.000

1.587 (1.024–2.459)

0.038

Swedish children

P**

 rs12186500 G>A

Normal weight

523

157 (30)

260 (50)

106 (20)

54.9

45.1

1.000

  

Obese

500

158 (32)

226 (45)

116 (23)

54.2

45.8

0.057

1.028 (0.863–1.223)

0.759

 rs1021001 C>G

Normal weight

517

398 (77)

109 (21)

10 (2)

88.0

12.0

0.419

  

Obese

499

360 (73)

127 (25)

12 (2)

85.0

15.0

1.000

1.193 (0.924–1.539)

0.086

 rs4285184 A>G

Normal weight

511

301 (59)

177 (35)

33 (6)

76.0

24.0

0.912

  

Obese

507

268 (53)

201 (40)

38 (7)

73.0

27.0

0.465

1.205 (0.987–1.471)

0.067

Greek children

P**

 rs12186500 G>A

Normal weight

1289

373 (29)

625 (48)

291 (23)

53.2

46.8

0.364

  

Overweight

928

264 (28)

444 (48)

220 (24)

52.4

47.6

0.211

1.035 (0.918–1.166)

0.577

Obese

261

84 (32)

114 (44)

63 (24)

54.1

45.9

0.061

0.948 (0.789–1.139)

0.572

 rs1021001 C>G

Normal weight

1294

965 (74)

311 (24)

18 (2)

86.6

13.4

0.845

  

Overweight

933

701 (75)

212 (23)

20 (2)

86.5

13.5

0.400

1.009 (0.847–1.202)

0.919

Obese

264

191 (72)

71 (27)

2 (1)

85.8

14.2

0.128

1.076 (0.828–1.396)

0.584

 rs4285184 A>G

Normal weight

1289

696 (54)

498 (39)

95 (7)

73.3

26.7

0.120

  

Overweight

931

488 (53)

366 (39)

77 (8)

72.1

27.9

0.464

1.063 (0.930–1.216)

0.367

Obese

265

122 (46)

125 (47)

18 (7)

69.7

30.3

0.080

1.192 (0.978–.454)

0.081

  1. Abbreviations: CI, confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; ULSAM, Uppsala Longitudinal Study of Adult Men.
  2. Data are number of subjects in each group and number of subjects for each genotype (G) (% in each group). Allele frequency (A) for each group is given in percentage. OR with a 95 % CI was calculated assuming an additive model. Association with overweight and obesity was determined comparing subjects with normal weight (BMI <25 kg m−2) and overweight (BMI ⩾25 kg m−2) and subjects with normal weight (BMI <25 kg m−2) and obesity (BMI ⩾30 kg m−2). HWE indicate P-values for deviation from Hardy–Weinberg equilibrium, excluded if P⩽0.001.
  3. * Indicates P-values adjusted for diabetes, hypertension and hyperlipidemia prevalence.
  4. ** Indicates P-values adjusted for age and gender.
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