Table 5 Association study of MGAT1 SNPs with insulin measurements in the three cohorts

From: Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

 

ULSAM

Swedish children

Greek children

 

β

P Add

β

P Add

β

P Add

rs12186500

 S-insulin

0.014

0.605

0.044

0.346

−0.006

0.061

 HOMA-IR

0.026

0.409

0.065

0.174

0.006

0.722

 Insulin response

0.005

0.876

0.115

0.012

—

—

 Insulin sensitivity

—

—

−0.108

0.015

—

—

rs1021001

 S-insulin

0.037

0.306

0.042

0.533

0.041

0.038

 HOMA-IR

0.045

0.293

0.057

0.430

−0.017

0.543

 Insulin response

0.001

0.982

0.222

0.001

—

—

 Insulin sensitivity

—

—

−0.131

0.030

—

—

rs4285184

 S-insulin

0.035

0.253

0.224

0.046

0.039

0.009

 HOMA-IR

0.002

0.533

0.083

0.155

0.011

0.587

 Insulin response

0.038

0.304

0.223

5.5x10−5

—

—

 Insulin sensitivity

—

—

−0.142

0.007

—

—

rs12517906

 S-insulin

0.028

0.450

    

 HOMA-IR

0.029

0.493

    

 Insulin response

−0.049

0.294

    

rs6886113

 S-insulin

−0.018

0.604

    

 HOMA-IR

−0.010

0.667

    

 Insulin response

0.013

0.729

    
  1. Abbreviations: HOMA-IR, homeostatic model assessment-insulin resistance; SNP, single nucleotide polymorphism; ULSAM, Uppsala Longitudinal Study of Adult Men.
  2. β indicates transformed β-values. PAdd indicates P-values adjusted for significant covariates.
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