Table 2 Offspring characteristics

From: Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue

 

22d Control

22d Recuperated

3m Control

3m Recuperated

 

(n=13)

(n=10)

(n=11)

(n=10)

Body weight (g)

50.1±1.5

51.6±1.8

369.5±12.1

405.2±14.7

Mean cumulative food intake, PND 28–70 (g)

—

—

1019±14

1044±31

Epididymal mass (g)

0.12±0.01

0.19±0.03 ^

5.3±0.3

5.9±0.4

Adipocyte area (μm2)

707

(268, 1337)

957***

(439, 1700)

2202

(570, 4068)

2928***

(1448, 4496)

Plasma glucose (mmol l−1)

4.4±0.3

5.0±0.3

4.3±0.2

4.6±0.2

Insulin (pmol l−1)

20 (13–30)

10 (5–22)

131 (81–212)

135 (85–213)†

Leptin (ng ml−1)

1.2±0.1

1.6±0.15

5.5±0.6

5.7±0.04†

Cholesterol (mmol l−1)

2.7±0.2

3.1±0.2

1.2±0.06

1.5±0.1†,#

Triglycerides (mmol l−1)

1.3±0.1

1.1±0.1

1.8±0.2

1.5±0.2†

Free fatty acids (μmol l−1)

687±35

762±33

850±71

818±77

  1. Abbreviation: PND, postnatal day.
  2. Control and recuperated rat offspring characteristics at 22 days (22d) and 3 months (3m) of age. Insulin data are presented as geometric means (95% confidence intervals) and were logged before statistical analysis. Adipocyte area is presented as median values (interquartile range). All other data are presented as mean±s.e.m. Plasma and serum measures were taken in the fasted state. Student’s t-test; ^P<0.05 vs same age control. Two-way analysis of variance; #P<0.05 for effect of maternal diet, †P<0.01 for effect of age. Mann–Whitney t-test, ***P<0.001 vs same aged controls.
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