Table 2 Anthropometric and metabolic characteristics of 5781 middle-aged untreated Danes (Inter99) stratified according to UCP2 −866G>A genotypes
GG | GA | AA | β (95% CI) | P | |
|---|---|---|---|---|---|
n (men/women) | 2164 (1087/1077) | 2694 (1331/1363) | 923 (451/472) | ||
Age (years) | 46±8 | 46±8 | 46±8 | ||
BMI (kg m−2) | 26.2±4.4 | 26.2±4.6 | 26.1±4.6 | −0.02 (−0.18; 0.15) | 0.9 |
Waist circumference (cm) | 86±13 | 87±13 | 86±14 | 0.17 (−0.03; 0.36) | 0.09 |
Waist-to-hip ratio | 0.86±0.08 | 0.86±0.09 | 0.86±0.09 | 0.001 (−0.001; 0.003) | 0.2 |
Plasma glucose (mmol l−1) | |||||
Fasting | 5.6±0.9 | 5.5±0.8 | 5.5±0.7 | −0.03 (−0.06; −0.01) | 0.02 |
30-min | 8.8±2.0 | 8.6±1.8 | 8.7±1.8 | −0.05 (−0.11; 0.02) | 0.2 |
120-min | 6.3±2.2 | 6.2±2.1 | 6.2±2.1 | −0.04 (−0.11; 0.04) | 0.3 |
AUC | 223±136 | 218±135 | 220±132 | −1.67 (−6.46; 3.11) | 0.5 |
Serum insulin (pmol l−1) | |||||
Fasting | 35 (25–53) | 34 (23–50) | 32 (23–49) | −3.0% (−4.9; −1.1) | 0.002 |
30-min | 247 (176–355) | 246 (176- 351) | 236 (170–348) | −1.1% (−3.1; 0.8) | 0.3 |
120-min | 158 (101–259) | 156 (95–254) | 152 (90–251) | −4.0% (−6.7; −1.2) | 0.005 |
AUC | 18 870 (13 120–27 740) | 18 680 (13 100–27 100) | 18 270 (12 740–26 670) | −1.8% (−3.9; 0.4) | 0.1 |
Insulin resistance (mmol l−1–pmol l−1) | |||||
HOMA-IR | 8.7 (5.8–13.4) | 8.1 (5.5–12.7) | 7.9 (5.4–12.2) | −3.5% (−5.5; −1.5) | 0.0007 |
BIGTT-SI | 9.1±4.1 | 9.3±4.1 | 9.5±4.1 | 0.17 (0.02; 0.33) | 0.03 |
Fasting serum lipids (mmol l−1) | |||||
Triglyceride | 1.1 (0.8–1.6) | 1.1 (0.8–1.5) | 1.0 (0.8–1.5) | −1.4% (−3.2; 0.4) | 0.1 |
Total cholesterol | 5.5±1.1 | 5.5±1.1 | 5.5±1.1 | −0.002 (−0.040; 0.035) | 0.9 |
HDL-cholesterol | 1.4±0.4 | 1.4±0.4 | 1.4±0.4 | −0.003 (−0.016; 0.010) | 0.7 |
