Figure 1

Expression of microRNAs (miRNAs) and potential targets of miRNA let-7g in fetal LD muscle of obese (OB ) versus control sheep (Con □). (a) Quantitative RT-PCR showed higher expression of miR-381, but less let-7g and miR-376d in OB fetal muscle than in Con muscle. (b) mRNA expression of TNFRSF4 and FST were increased in OB compared with Con fetal muscle, both are potential targets of hsa-let-7g. (c) mRNA expression of tumor necrosis factor α and IL-6 were higher in OB compared with Con fetal muscle (*P<0.05, ^§P<0.10 when compared with Con; Mean±s.e.m.; n=10 in Con and n=10 in OB group).