Figure 7

(a) Effect of PPARδ-agonist on HO-1 expression in adipose tissue in 2K1C animals—treated with and without GW 501516 or GW 501516+SnMP. Western blot and densitometry analysis of HO-1 levels; *P<0.05 vs control, #P<0.05 vs 2K1C. Results are means±s.e., n=6/group; Data are shown as mean band density normalized to β-actin. (b) HO-1 promoter activity, as determined in Cos 7 cells by the luciferase assay. ***P<0.05 vs without PPARδ; **P<0.05 vs with PPARδ but without GW.