Table 3 Multivariate analyses: DNA methylation at the DMRs in the offspring in relation to obesity of the parents

From: Newborns of obese parents have altered DNA methylation patterns at imprinted genes

 

MEG3-IG

MEG3

MEST

NNAT

PEG3

PLAGL1

SGCE/PEG10

 

β

s.e.

P

β

s.e.

P

β

s.e.

P

β

s.e.

P

β

s.e.

P

β

s.e.

P

β

s.e.

P

Model 1

 Father obese

+0.38

1.43

0.79

+1.04

1.47

0.48

−2.50

0.84

0.003

−3.04

1.45

0.04

−1.70

0.62

0.007

+1.39

1.47

0.34

+1.26

0.99

0.10

Model 2

 Mother obese

+0.20

1.26

0.87

−2.94

1.57

0.06

−0.98

0.66

0.14

−0.88

1.26

0.48

−0.02

0.56

0.97

+3.03

0.86

0.0005

+1.08

0.68

0.11

Model 3

 Father obese

+0.34

1.71

0.84

+2.75

1.74

0.11

−2.57

0.95

0.008

−3.59

1.76

0.04

−1.71

0.61

0.005

+2.19

1.33

0.10

+1.26

0.80

0.12

 Mother obese

+0.11

1.57

0.95

−3.42

1.69

0.04

+0.37

0.81

0.65

+0.85

1.60

0.59

+0.46

0.60

0.47

+2.58

1.00

0.01

+1.02

0.75

0.17

  1. Abbreviations: MEG3, maternally expressed gene 3; MEST, mesoderm-specific transcript; NNAT, neuronatin; PEG3, paternally expressed gene 3; PLAGL1, pleiomorphic adenoma gene-like 1; SGCE/PEG10, epsilon sarcoglycan and paternally expressed gene 10.
  2. Obesity was defined as BMI⩾30 kg m−2. All the models were adjusted by age, race, education, smoking status of the mother, gender of the offspring, clusters of experimental tests and CpG sites measured. Model 1 includes paternal obesity, model 2 includes maternal obesity and model 3 includes both paternal and maternal obesity.
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