Figure 4
From: Maternal obesity is associated with a reduction in placental taurine transporter activity
(a) TauT activity at day 7 of culture is higher in placental villous explants maintined in medium with no added taurine (▴) compared with that with 100 μm added taurine (●). (a) Representative culture (least squares linear regression). (b) TauT activity in explants at day 7 of culture in medium with 100 μm added taurine (●) was not significantly different from activity determined in freshly isolated tissue fragments from the same placenta (○) (mean±s.e.; n=3 placentas; least squares linear regression). (c) Time course of hCG secretion by untreated placental villous explants over 7 days of culture (mean±s.e.; n=5) indicated endocrine viability. (d) TauT activity (90 min) in explants at day 7 of culture, expressed as a percentage of the controls (100%; dotted line), was unaffected by 48 h exposure to either leptin or IL-6 (Wilcoxon signed rank test vs control (100%): median and interquartile range; n=5).
